货号：MAB1639

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Villin Antibody, clone 12 | MAB1639 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts strongly with one major band and several minor bands on Western blots of purified villin and total extracts from rabbit intestine.Villin is a 95 kDa protein composed of two very similar domains of approximately 44 kDa each, the core, and a C-terminal domain of 8 kDa, the headpiece. The core has been shown to contain villin's Ca++-regulated capping, nucleating and severing activities, but it cannot induce the formation of microfilament bundles without the headpiece. Villin has been shown to be a useful differentiation marker of early embryogenesis and may be useful in diagnosis and follow-up of colorectal cancers. It has been demonstrated that villin is necessary for both the cytoskeletal and membrane protein organization of a functional brush border. View All» Immunogen: Villin purified from chicken intestine. View All» Clone: 12 View All» Isotype: IgG1 View All» Species Reactivity:

• Chicken

• Human
  View All» Application Notes: Western blot: 1:1,000. Immunocytochemistry Optimal working dilutions must be determined by end user. View All» Control: CONTROL LYSATE: Suggested control is HTC-8 lysate prepared from an epithelial-like cell line (ATCC# CCl244) that was developed from a human ileocecal adenocarcinoma. View All» Presentation: Purified immunoglobulin. Liquid in aqueous buffered solution containing ≤ 0.09% sodium azide. View All» Storage Conditions: Maintain antibody and control lysate at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P09327 View All» Entrez Gene Number: NM_007127.1 View All» Gene Symbol:
  • VIL1

  • VIL

  • D2S1471

  • Villin-1.
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of a family of calcium-regulated actin-binding proteins. This protein represents a dominant part of the brush border cytoskeleton which functions in the capping, severing, and bundling of actin filaments. Two mRNAs of 2.7 kb and 3.5 kb have been observed; they result from utilization of alternate poly-adenylation signals present in the terminal exon. View All» UniProt Summary: FUNCTION: SwissProt: P09327 # Ca(2+)-regulated actin-binding protein.SIZE: 827 amino acids; 92695 Da SUBUNIT: Monomer.SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.TISSUE SPECIFICITY: Major component of microvilli of intestinal epithelial cells and kidney proximal tubule cells.DOMAIN: SwissProt: P09327 Consists of a large core fragment, the N-terminal portion, and a small headpiece, the C-terminal portion. The headpiece binds F-actin strongly in both the presence and absence of calcium.SIMILARITY: Belongs to the villin/gelsolin family. & Contains 6 gelsolin-like repeats. & Contains 1 HP (headpiece) domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Villin Antibody, clone 12 | MAB1639 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 150 µg View All» Format: Purified View All» Host: Mouse View All»
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