货号：MAB1669

品牌：Merck Millipore

规格：

目录价：￥3552.00

市场价格：￥3019.20

会员价格：￥2841.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-VEGF Receptor-2 Antibody, clone 89B3A5 | MAB1669 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: FLK-1 is a receptor tyrosine kinase expressed on endothelial cells and on the common precursor of endothelial and hematopoietic stem cells Antibodies against FLK-1 are suitable for studies for endothelial development, for embryonal hematopoiesis, and for signal transduction via the FLK-1 receptor. It has not been tested whether the antibody blocks the binding of VEGF. View All» Immunogen: Rat L cells transfected with the complete coding sequence of mouse FLK-1 cDNA. View All» Clone: 89B3A5 View All» Isotype: IgG2a View All» Species Reactivity: Mouse View All» Application Notes: Immunoblotting Immunoprecipitation FACS Analysis Optimal working dilutions must be determined by end user. View All» Presentation: Protein G purified immunoglobulin View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 12 months. View All» UniProt Number:

• P15692

• P35918
  View All» Gene Symbol: VEGFR2 View All» Alternate Names: FLK-1; KDR View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Flow Cytometry

  • Immunoprecipitation

  • Western Blotting
    View All» Entrez Gene Summary: This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. View All» UniProt Summary: FUNCTION: SwissProt: P15692 # Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Binds to the VEGFR1/Flt-1 and VEGFR2/Kdr receptors, heparan sulfate and heparin. Neuropilin-1 binds isoforms VEGF-165 and VEGF-145.SIZE: 232 amino acids; 27042 Da SUBUNIT: Homodimer; disulfide-linked. Also found as heterodimer with PlGF (By similarity).SUBCELLULAR LOCATION: Secreted. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.TISSUE SPECIFICITY: The VEGF189, VEGF-165 and VEGF-121 isoforms are widely expressed, whereas the VEGF206 and VEGF-145 are uncommon.SIMILARITY: SwissProt: P15692 ## Belongs to the PDGF/VEGF growth factor family. View All» Brand Family: Chemicon View All» Product Name: Anti-VEGF Receptor-2 Antibody, clone 89B3A5 | MAB1669 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rat View All»
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