货号：MAB1675

品牌：Merck Millipore

规格：1EA

目录价：￥3736.91

市场价格：￥3176.37

会员价格：￥2989.53

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cytokeratin 19 Antibody, clone E6 | MAB1675 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Rat keratin 19 (40kD), analogous to human keratin 19. View All» Immunogen: Keratin from rat colon. View All» Clone: E6 View All» Isotype: IgG1 View All» Species Reactivity:

• Rat

• Rabbit

• Xenopus

• Fish
  View All» Non-Reactive Species:
  • Human

  • Mouse
    View All» Application Notes: Immunohistochemistry frozen tissue sections. Immunoblotting Optimal working dilutions must be determined by end user. View All» Presentation: Liquid View All» Storage Conditions: Maintain frozen at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number:
    • P08727

    • Q63279
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» Entrez Gene Summary: The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. View All» UniProt Summary: FUNCTION: SwissProt: P08727 # Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.SIZE: 400 amino acids; 44092 Da SUBUNIT: Heterotetramer of two type I and two type II keratins. Interacts with PNN and the actin-binding domain of DMD. Interacts with HCV core protein.TISSUE SPECIFICITY: Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin.DEVELOPMENTAL STAGE: Present in hair follicles at all stages of development.DOMAIN: SwissProt: P08727 This keratin differs from all other IF proteins in lacking the C-terminal tail domain.SIMILARITY: Belongs to the intermediate filament family. MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). View All» Brand Family: Chemicon View All» Product Name: Anti-Cytokeratin 19 Antibody, clone E6 | MAB1675 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Target / Localization: Many simple epithelial cells; glandular type epithelia and carcinomas View All» Format: Ascites View All» Host: Mouse View All»
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