货号：MAB1698

品牌：Merck Millipore

规格：100Ug

目录价：￥3466.00

市场价格：￥2946.10

会员价格：￥2772.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Desmin Antibody, clone 131-15014 (KN50-1-4) | MAB1698 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Desmin View All» Clone: 131-15014 (KN50-1-4) View All» Isotype: IgG1 View All» Species Reactivity:

• Bovine

• Human
  View All» Non-Reactive Species: Rabbit View All» Application Notes: Immunocytochemistry: approximate concentration 40 μg/mL Immunohistochemistry (frozen or de-paraffinized tissue): approximate concentration 40 μg/mL Optimal dilutions must be determined by end user. View All» Presentation: Purified immunoglobulin. Liquid in 10 mM Phosphate buffer, 150 mM NaCl, pH 7.4, containing 0.1% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P17661 View All» Entrez Gene Number: NM_001927.3 View All» Gene Symbol:
  • DES

  • CSM2

  • FLJ41793

  • FLJ41013

  • FLJ39719

  • CSM1

  • FLJ12025

  • Desmin.

  • CMD1I

  • desmin
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. View All» UniProt Summary: FUNCTION: SwissProt: P17661 # Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.SIZE: 470 amino acids; 53536 Da SUBUNIT: Homopolymer.SUBCELLULAR LOCATION: Cytoplasm.DISEASE: SwissProt: P17661 # Defects in DES are the cause of desmin-related cardio- skeletal myopathy (CSM) [MIM:601419]; also known as desmin-related myopathy (DRM). CSM is characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by intracytoplasmic accumulation of desmin-reactive deposits in cardiac and skeletal muscle cells. A desmin-related myopathy can have a distal onset, it is then known as hereditary distal myopathy (HDM). & Defects in DES are the cause of dilated cardiomyopathy 1I (CMD1I) [MIM:604765]. CMD1I is an autosomal form of dilated cardiomyopathy characterized by ventricular dilatation and impaired systolic function.SIMILARITY: SwissProt: P17661 ## Belongs to the intermediate filament family. View All» Brand Family: Chemicon View All» Product Name: Anti-Desmin, clone 131-15014 (KN50-1-4) View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Target / Localization: Most muscle types and pericytes View All» Format: Purified View All» Host: Mouse View All»
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