货号：05-1921

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho IRS1 (Ser522), clone 17.5.2 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes IRS1 phosphorylated at Ser522. View All» Molecular Weight: ~ 160 kDa View All» Epitope: Ser522 View All» Immunogen: KLH-conjugated linear peptide corresponding to rat IRS1 phosphorylated at Ser522. View All» Clone: 17.5.2 View All» Isotype: IgG3κ View All» Background Information: IRS1 (Insulin Receptor Substrate 1) transmits insulin signals via metabolic and mitogenic pathways. IRS1 is heavily phosphorylated on both serine and tyrosine residues. These phosphorylated tyrosines enable IRS to act as a docking protein that binds SH2 domains of such proteins as PI3 Kinase (phosphatidylinositol 3-kinase) and GRB2, resulting in activation. Over expression and phosphorylation of serine is associated with insulin resistance and breast cancer. Some of the more notable phosphorylation sites are Ser302 that is phosphorylated following insulin stimulation. Ser307, phosphorylated by JNK and IKK, is a key regulatory site that appears to disrupt the IRS1/IR interaction and inhibits insulin-mediated activation of the PI3 kinase and MAPK pathways, and Ser636/639 that is known to be phosphorylated by p70S6K downstream of mTOR and acts as a negative feedback loop. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human and rat. View All» Control: Calyculin/Okadaic Acid treated and untreated CHO-IR/IRS1 cell lysates View All» Quality Assurance: Evaluated by Western Blot in Calyculin/Okadaic Acid treated and untreated CHO-IR/IRS1 cell lysates.Western Blot Analysis: 0.1 µg/mL of this antibody detected IRS1 on 10 µg of Calyculin/Okadaic Acid treated and untreated CHO-IR/IRS1 cell lysates. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG3κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) without 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P35569 View All» Entrez Gene Number: NP_034700 View All» Gene Symbol:

• HIRS-1

• IRS-1
  View All» Alternate Names: Insulin Receptor Substrate 1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: IRS1 (Insulin Receptor Substrate 1) transmits insulin signals via metabolic and mitogenic pathways. IRS1 is heavily phosphorylated on both serine and tyrosine residues. These phosphorylated tyrosines enable IRS to act as a docking protein that binds SH2 domains of such proteins as PI3 Kinase (phosphatidylinositol 3-kinase) and GRB2, resulting in activation. Over expression and phosphorylation of serine is associated with insulin resistance and breast cancer. Some of the more notable phosphorylation sites are Ser302 that is phosphorylated following insulin stimulation. Ser307, phosphorylated by JNK and IKK, is a key regulatory site that appears to disrupt the IRS1/IR interaction and inhibits insulin-mediated activation of the PI3 kinase and MAPK pathways, and Ser636/639 that is known to be phosphorylated by p70S6K downstream of mTOR and acts as a negative feedback loop. View All» UniProt Summary: FUNCTION: May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor it binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. Interacts with SOCS7 By similarity.SUBUNIT STRUCTURE: Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR via the PTB domain. Binds to phosphatidylinositol 3-kinase p85 subunit via the phosphorylated YXXM motifs. Binds ROCK1 By similarity. Binds to UBTF and PIK3CA in nuclear extracts.TISSUE SPECIFICTY: Expressed in osteoblasts, but not in osteoclasts. PTM: Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-307 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor by similarity.Phosphorylation of Tyr-891 is required for GRB2-binding By similarity.SEQUENCE SIMILARITIES: Contains 1 IRS-type PTB domain.Contains 1 PH domain. View All» Product Name: Anti-phospho IRS1 (Ser522), clone 17.5.2 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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