货号：MAB1789

品牌：Merck Millipore

规格：100Ug

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Migration Inhibitory Factor Related Proteins 8 and 14 Antibody, clone AHN-17 View All» Replaces: CBL269 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Migration Inhibitory Factor Releasing Proteins -8 and -14 View All» Immunogen: Neutrophils View All» Clone: AHN-17 View All» Isotype: IgG1 View All» Background Information: Migration inhibitory factor-related proteins (MRP) -8 and -14 belong to the S-100 family of calcium binding proteins associated with myeloid cell differentiation. They are highly expressed in resting neutrophils, keratinocytes (particularly in psoriasis), in infiltrating tissue macrophages and on epithelial cells in active inflammatory disease. The heterogeneity of macrophage subpopulations in chronic or acute inflammation is reflected by different expression of MRP8 and MRP14. Phagocytes expressing MRP8 and MRP14 belong to the early infiltrating cells, while MRP8 alone is found in chronic inflammatory tissues. The partially antagonistic functions of MRP8, MRP14 and of the Ca2+-dependent MRP8/14 heterocomplex makes them versatile mediators. View All» Species Reactivity: Human View All» Application Notes: Immunocytochemistry on ethanol fixed cells Immunoblotting on un-reduced gels Optimal dilutions must be determined by the end user. View All» Presentation: Purified immunoglobulin. Liquid in 0.02M Phosphate buffer, 0.25M NaCl with 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 6 months from date of receipt. View All» UniProt Number: P05109 View All» Entrez Gene Number: NM_002964.3 View All» Gene Symbol:

• S100A8

• CFAG

• Calgranulin-A

• 60B8AG

• MRP8

• CGLA

• L1Ag

• MIF

• MRP-8

• MA387

• CAGA

• CP-10

• NIF

• P8
  View All» Alternate Names: MRP-8 & 9; Myeloid-Related Protein-8 & 9; Calgranulin A & B; S100 Calcium-binding Protein A8 & A9; Leukocyte L1 cplx Light & Heavy Chain; Calprotectin View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunocytochemistry
    View All» Entrez Gene Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. View All» UniProt Summary: FUNCTION: SwissProt: P05109 # Expressed by macrophages in chronic inflammations. Also expressed in epithelial cells constitutively or induced during dermatoses. May interact with components of the intermediate filaments in monocytes and epithelial cells.SIZE: 93 amino acids; 10835 Da SUBUNIT: Homodimer.SIMILARITY: SwissProt: P05109 ## Belongs to the S-100 family. & Contains 2 EF-hand domains. MISCELLANEOUS: Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins. View All» Brand Family: Chemicon View All» Product Name: Anti-Migration Inhibitory Factor Related Proteins 8 and 14 Antibody, clone AHN-17 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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