货号：MAB1794H

品牌：Merck Millipore

规格：100assays

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CD19 Antibody, clone FMC63, Phycoerythrin conjugated | MAB1794H View All» Replaces: CBL141P View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Product Overview: BIOCHEMISTRY: p I = 7.0 View All» Specificity: This specificity of this antibody is equivalent to that of CD19 monoclonal antibodies (Zola et al., 1988, 1989), based on comparative studies, antigen recognition and positive reaction with a CD19 transfected cell line. It detects a 96 kD single chain glycoprotein on the surface of human B lineage cells, including pre-B cells. B cells can be detected in peripheral blood and tissues. The antibody reacts with most B cell malignancies including chronic lymphocytic leukemia and most lymphomas, but not multiple myeloma. Cell reactivity: Normal:Stains all B lymphocytes in peripheral blood and spleen. Negative on granulocytes, monocytes, platelets, erythrocytes and T lymphocytes. Clinical: B cell chronic lymphocytic leukemia (B-CLL) + Pro lymphocytic leukemia (PLL + Hairy cell leukemia (HCL) + Common acute lymphoblastic leukemia (CALL) + Pre-B acute lymphoblastic leukemia (pre-B-ALL) + NULL-acute lymphoblastic leukemia (NULL-ALL) + T-acute lymphoblastic leukemia (T-ALL) - T-common lymphocytic leukemia (T-CLL - View All» Immunogen: Raji cells View All» Clone: FMC63 View All» Isotype: IgG2a View All» Species Reactivity: Human View All» Application Notes: This antibody is useful for enumerating normal B lymphocytes and typing B cell malignancies by flow cytometry. SUGGESTED USAGE Flow cytometry - use 10 μl direct from the vial per 100 μl of whole blood, or 1 x 10E(6) peripheral blood mononuclear cells (PBMC) in 100 μl buffer. View All» Presentation: Purified from mouse ascitic fluid. R-Phycoerythrin conjugated. The antibody is supplied in 1.0ml phosphate buffered saline, pH 7.4, containing 0.2% bovine serum albumin and 0.1% sodium azide. The characteristics of each lot are tested by electrophoresis and flow cytometry. View All» Storage Conditions: Store at 2 to 8°C, for up to 6 months. DO NOT FREEZE. Protect from light. WARNING: The monoclonal reagent solution contains 0.1% sodium azide as a preservative. Due to potential hazards arising from the build up of this material in pipes, spent reagent should be disposed of with liberal volumes of water. View All» UniProt Number: P15391 View All» Entrez Gene Number: NM_001770.4 View All» Gene Symbol:

• CD19

• B4

• MGC12802

• Leu-12
  View All» Alternate Names: B-lymphocyte Surface Antigen B4 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Flow Cytometry View All» Entrez Gene Summary: Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. View All» UniProt Summary: FUNCTION: SwissProt: P15391 # Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.SIZE: 556 amino acids; 61128 Da SUBUNIT: Forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.DISEASE:SwissProt: P15391 # Defects in CD19 are a cause of hypogammaglobulinemia [MIM:107265].SIMILARITY: SwissProt: P15391 ## Contains 2 Ig-like C2-type (immunoglobulin-like) domains. View All» Brand Family: Chemicon View All» Product Name: Anti-CD19 Antibody, clone FMC63, Phycoerythrin conjugated | MAB1794H View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 assays View All» Format: Phycoerythrin View All» Host: Mouse View All»
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  © Merck Millipore代理MAB1794H Anti-Human B cells (CD19) Antibody, clone FMC63, Phycoerythrin conjugated;store at +2℃ to +8℃，产品报价联系微信jinshanbio