货号：MAB19101

品牌：Merck Millipore

规格：50Ug

目录价：￥7970.00

市场价格：￥6774.50

会员价格：￥6376.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Tenascin Antibody, clone DB7 | MAB19101 View All» Replaces: MAB1902 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: The antibody recognizes the Mr 250000 and 180000 tenascin polypeptides in immunoprecipitation and immunoblots the Mr 250000 polypeptide. The antibody reacts with the fibrinogen-like knob-domain of tenascin protein View All» Immunogen: Tenascin polypeptides isolated from spent culture supernatant of human fibroblasts isolated by affinity chromatography. View All» Clone: DB7 View All» Isotype: IgG2a View All» Species Reactivity:

• Guinea Pig

• Human

• Rabbit
  View All» Non-Reactive Species:
  • Mouse

  • Rat
    View All» Application Notes: Immunofluorescence: 1-2% PFA fixed, permeabilized tissues or cell cultures. Mild pepsin digestion improves staining. Immunohistochemistry (formalin-fixed and paraffin-embedded sections): 1:200-1:400. Requires pepsin digestion (0.1-.4% pepsin in .1% HCL pH 1.0, 30-50 minutes at 37C; neutralize sections with 2 quick rinses in 1X PBS pH 7.4 prior to blocking and antibody staining. Enhanced ABC or amplified detection systems recommended for best signals. See Soini, Y 1993 J Clin Patholo for protocol for decalified bone. Immunoblotting: 1:1000; SDS sample buffer lysis of whole human fibroblasts; 6.5% PAGE reduced gels. Two distinct bands, 250,000 & 190,000 {Soini, Y Am. J. Clin. Path. 1993) Final dilutions must be determined by end user. View All» Presentation: The purified antibody is in PBS solution containing 1.0% (w/v) BSA and 0.1% (w/v) sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C View All» UniProt Number: P24821 View All» Gene Symbol:
    • ITGAM

    • MO1A

    • CD11b

    • CR3A

    • MAC1A

    • CD11B

    • MGC117044

    • MAC-1
      View All» Alternate Names: Tenascin-C View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunofluorescence

      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» UniProt Summary: FUNCTION: SwissProt: P11215 # Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.SIZE: 1152 amino acids; 127179 Da SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Predominantly expressed in monocytes and granulocytes.DOMAIN: SwissProt: P11215 The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.SIMILARITY: Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. & Contains 1 VWFA domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Tenascin Antibody, clone DB7 | MAB19101 View All» Concentration: 50 ug immunoglobulin in 500 uL buffer View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Purified View All» Host: Mouse View All»
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