货号：05-1952

品牌：Merck Millipore

规格：100Ug

目录价：￥4607.00

市场价格：￥3915.95

会员价格：￥3685.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SETDB2 Antibody, clone 5B7.2 | 05-1952 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~ 80 kDa observed View All» Immunogen: Recombinant protein corresponding to human SETDB2. View All» Clone: 5B7.2 View All» Isotype: IgMκ View All» Background Information: SET domain bifurcated 2 (SETDB2), also known as Histone-lysine N-methyltransferase SETDB2 is a ubiquitous, nuclear protein belonging to the histone-lysine methyltransferase family and is comprised of a MBD (Methyl-CpG-binding) domain, a pre-SET domain, and a SET domain. Data suggests that SETDB2 is a methyltransferase with specific activity against histones. Studies also suggest that it may be a key regulatory component in the development of dorsal organizer and left-right asymmetry during early embryonic development by downregulating fibroblast growth factor 8. Although expression of the protein is considered ubiquitous, high levels have been reported in heart, ovary and testis tissues. View All» Species Reactivity:

• Mouse

• Human
  View All» Species Reactivity Note: Demonstrated to react with mouse and human. View All» Control: A431 cell lysate View All» Quality Assurance: Evaluated by Western Blot in A431 cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected SETDB2 on 10 µg of A431 cell lysate. View All» Purification Method: Ion Exchange View All» Presentation: Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q96T68 View All» Entrez Gene Number: NP_001153780 View All» Gene Symbol:
  • SETDB2

  • CLLD8

  • KMT1F

  • CLLL8
    View All» Alternate Names:
    • SET domain, bifurcated 2

    • chromosome 13 open reading frame 4

    • chronic lymphocytic leukemia deletion region 8

    • Lysine N-methyltransferase 1F

    • histone-lysine N-methyltransferase SETDB2

    • Chronic lymphocytic leukemia deletion region gene 8 protein

    • SET domain bifurcated 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510]).[supplied by OMIM]. View All» UniProt Summary: FUNCTION: Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis. CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SUBCELLULAR LOCATION: Nucleus. Chromosome Probable TISSUE SPECIFICTY: Ubiquitous. Highest expression in heart, testis and ovary.SEQUENCE SIMILARITIES: Belongs to the histone-lysine methyltransferase family.Contains 1 MBD (methyl-CpG-binding) domain.Contains 1 pre-SET domain.Contains 1 SET domain.SEQUENCE CAUTION: The sequence CAH56265.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.The sequence CAI10818.2 differs from that shown. Reason: Erroneous gene model prediction. View All» Product Name: Anti-SETDB2, clone 5B7.2 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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