货号：MAB1936

品牌：Merck Millipore

规格：

目录价：￥3627.00

市场价格：￥3082.95

会员价格：￥2901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Fibronectin Antibody, N-terminus, clone 616 | MAB1936 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with whole human fibronectin and many of its proteolytic fragments. Specifically recognizes N-terminal fibrin- and heparin-binding 29 kDa domain. Specificity established by Western blotting with purified domain from two different sources. View All» Molecular Weight: 29 kDa View All» Epitope: N-terminus View All» Immunogen: Proteins secreted by cultured human embryonic fibroblasts. View All» Clone: 616 View All» Isotype: IgG3 View All» Species Reactivity: Human View All» Application Notes: Western blotting Immunoprecipitation RIA Indirect immunofluorescence and immunoperoxidase. For best results in tissue staining, use cryostat sections fixed with either acetone or 4% formaldehyde. Has not been tested on paraffin embedded tissue. Final working dilutions must be determined by end user. View All» Control: Extracellular matrix in most tissue View All» Purification Method: Protein A purfied View All» Presentation: Protein A Purified mouse immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative. View All» Storage Conditions: Long Term Storage - Maintain frozen at -20°C for up to 12 months in undiluted aliquots. Short Term Storage - Maintain at -2–8°C with 0.1% sodium azide for 1-6 weeks. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P02751 View All» Entrez Gene Number:

• NM_002026.2

• NM_054034.2

• NM_212474.1

• NM_212475.1

• NM_212476.1

• NM_212478.1

• NM_212482.1
  View All» Gene Symbol:
  • FN1

  • DKFZp686H0342

  • DKFZp686I1370

  • MSF

  • CIG

  • LETS

  • DKFZp686O13149

  • FN

  • DKFZp686F10164

  • FINC
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunohistochemistry

    • Immunoprecipitation

    • Radioimmunoassay

    • Western Blotting
      View All» Entrez Gene Summary: This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. View All» UniProt Summary: FUNCTION: SwissProt: P02751 # Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Interaction with TNR mediates inhibition of cell adhesion and neurite outgrowth (By similarity).SIZE: 2386 amino acids; 262607 Da SUBUNIT: Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, TNR, LGALS3BP and COL13A1.SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.TISSUE SPECIFICITY: Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine.DEVELOPMENTAL STAGE: Ugl-Y1, Ugl-Y2 and Ugl-Y3 are present in the urine from 0 to 17 years of age.PTM: Sulfated.SIMILARITY: SwissProt: P02751 ## Contains 12 fibronectin type-I domains. & Contains 2 fibronectin type-II domains. & Contains 16 fibronectin type-III domains. View All» Brand Family: Chemicon View All» Product Name: Anti-Fibronectin Antibody, N-terminus, clone 616 | MAB1936 View All» Concentration: 2.15 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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