货号：07-2046

品牌：Merck Millipore

规格：100Ug

目录价：￥6671.00

市场价格：￥5670.35

会员价格：￥5336.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-EHMT1 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~138 kDa View All» Epitope: Internal View All» Immunogen: The immunogen was a KLH-conjugated synthetic peptide corresponding to an internal region of human EHMT1. View All» Background Information: EHMT1 (euchromatic histone methyltransferase 1), also known as G9a-like protein (GLP1), is a histone methyltransferase. This protein specifically methylates Lysine 9 of histone H3 in vitro. H3Lys9 methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. EHMT1 is thought to be targeted to histone H3 by different DNA-binding proteins including E2F6, MGA, MAX and/or DP1. During G0 phase, it contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in the G0/G1 transition of the cell cycle. EMHT1/GLP1 is phosphorylated upon DNA damage, probably by ATM or ATR. Defects in EHMT1 result in severe mental retardation, hypotonia, and epileptic seizures. View All» Species Reactivity: Human View All» Species Reactivity Note: Recognizes human and murine EMHT1. Not tested in other species. View All» Application Notes: Western Blot AnalysisThis antibody recognized EMHT1 in transfected 293 cell lysates.ELISA:This antibody is reported by an outside laboratory to be suitable for ELISA View All» Control: A431, HeLa, or NIH/3T3 cells View All» Quality Assurance: ImmunocytochemistryDetects EHMT1 in the nuclei of A431, HeLa, or NIH/3T3 cells in immunofluorescent analysis. View All» Purification Method: Protein A chromatography View All» Presentation: Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial to pellet the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q9H9B1 View All» Entrez Gene Number: NP_079033 View All» Gene Symbol:

• DEL9q34

• DKFZp667M072

• EC 2.1.1.43

• EUHMTASE1

• Eu-HMTase1

• FLJ12879

• FP13812

• GLP

• GLP1

• KIAA1876

• KMT1D

• OTTHUMP00000022711

• bA188C12.1
  View All» Alternate Names:
  • G9a like protein

  • G9a-like protein 1

  • H3-K9-HMTase 5

  • Histone H3-K9 methyltransferase 5

  • Lysine N-methyltransferase 1D

  • euchromatic histone methyltransferase 1

  • euchromatic histone-lysine N-methyltransferase 1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • ELISA

    • Western Blotting
      View All» Entrez Gene Summary: The protein encoded by this gene is a histone methyltransferase that is part of the E2F6 complex, which represses transcription. The encoded protein methylates the Lys-9 position of histone H3, which tags it for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. View All» UniProt Summary: FUNCTION:Histone methyltransferase. Methylates 'Lys-9' of histone H3 (in vitro). H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle.Catalytic activity S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine. Ref.1SUBUNIT STRUCTURE: Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts with WIZ and EHMT2. Ref.10SUBCELLULAR LOCATION: Nucleus. Note= Associates with euchromatic regions.TISSUE SPECIFICITY: Widely expressed. Ref.5DOMAIN:The SET domain mediates interaction with WIZ.PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.11DISEASE: Defects in EHMT1 are the cause of chromosome 9q subtelomeric deletion syndrome (9q- syndrome) [MIM:610253]. Common features seen in these patients are severe mental retardation, hypotonia, brachy(micro)cephaly, epileptic seizures, flat face with hypertelorism, synophrys, anteverted nares, cupid bow or tented upper lip, everted lower lip, prognathism, macroglossia, conotruncal heart defects, and behavioral problems.Sequence similarities Belongs to the histone-lysine methyltransferase family.Contains 8 ANK repeats.Contains 1 pre-SET domain.Contains 1 SET domain.SEQUENCE CAUTION:The sequence CAD28534.1 differs from that shown. Reason: Miscellaneous discrepancy. Intron retention. View All» Product Name: Anti-EHMT1 View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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