货号：07-2050

品牌：Merck Millipore

规格：

目录价：￥4997.00

市场价格：￥4247.45

会员价格：￥3997.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-DNMT3A2 Antibody | 07-2050 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes isoform 2 of human DNMT3A. Additional lower molecular weight bands are detected in some samples. View All» Molecular Weight: ~80 kDa View All» Epitope: C-terminus View All» Immunogen: The immunogen was a KLH-conjugated synthetic peptide corresponding to the C-terminal region of human DNMT3A2. View All» Modifications: Methylation View All» Background Information: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. DNMT3 is a developmentally regulated DNA methyltransferase. DNMT3A2 is a second isoform of DNMT3 that is expressed from an alternative promoter. DNMT3A2 localizes to euchromatin and is thought to function in de novo methylation, rather than maintenance methylation. Binding of DNMT3L (DNMT3-like protein) to DNMT3A2 promotes a dramatic reorganization of DNMT3A2 subunits and leads to the formation of specific complexes with enhanced DNA methyltransferase activity. DNMT3A2 targets endogenous DNMT3L to embryonic stem cell chromatin and induces regional DNA methylation. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. Other homologies: Predicted to react with Mouse and Rat based on 100% sequence homology View All» Application Notes: ELISA: This antibody was shown by an outside laboratory to be suitable for ELISA.Immunocytochemistry: This antibody detects DMNT3A2 in the nuclei of NIH/3T3, HeLa, and A431 cells. View All» Control: L6, NIH/3T3, HeLa, or A431 cells. View All» Quality Assurance: Western Blot Analysis: 1:1,000 dilution of this antibody detected DNMT3A2 on 10 µg of L6 lysate. View All» Purification Method: Protein A chromatography View All» Presentation: Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial to pellet the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q9Y6K1 View All» Entrez Gene Number: NP_715640 View All» Gene Symbol:

• DNMT3A2

• Dnmt3a

• EC 2.1.1.37

• M.HsaIIIA

• OTTHUMP00000120005

• OTTHUMP00000120006
  View All» Alternate Names:
  • DNA (cytosine-5-)-methyltransferase 3 alpha

  • DNA MTase HsaIIIA

  • DNA cytosine methyltransferase 3 alpha

  • DNA cytosine methyltransferase 3A2

  • DNA methyltransferase HsaIIIA
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • ELISA

    • Western Blotting
      View All» Entrez Gene Summary: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]. View All» UniProt Summary: FUNCTION:Required for genome wide de novo methylation and is essential for development. DNA methylation is coordinated with methylation of histones. Ref.10Catalytic activity S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.SUBUNIT STRUCTURE: Binds the ZNF238 transcriptional repressor. Interacts with SETDB1. Associates with HDAC1 through its ADD-type zinc-finger By similarity. Interacts with DNMT1 and DNMT3B. Interacts with the PRC2/EED-EZH2 complex.SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Ref.3TISSUE SPECIFICITY: Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung. Ref.7Sequence similarities Belongs to the C5-methyltransferase family.Contains 1 ADD-type zinc finger.Contains 1 PWWP domain.CAUTION:It is uncertain whether Met-1 or Met-4 is the initiator View All» Product Name: Anti-DNMT3A2 Antibody View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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