货号：07-2066

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-DOT1L View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the C-terminal region of human DOT1L. View All» Molecular Weight: ~185 kDa View All» Epitope: C-terminus View All» Immunogen: The immunogen was a KLH-conjugated synthetic peptide corresponding to the C-terminal region of human DOT1L. View All» Background Information: DOT1L (DOT1-like, the mammalian homologue of yeast DOT1), is a DNA-binding protein that acts as a histone methyltransferase. DOT1L di- and trimethylates histone H3 on lysine 79, and is thought to be the sole enzyme responsible for this mark. DOT1L and H3K79 methylation play important roles in heterochromatin formation and in embryonic development. In contrast to other lysine histone methyltransferases, DOT1L does not contain a SET domain, suggesting a unique mechanism for methylation of lysines in histones DOT1L is associated with activating genes associated with acute leukemia by deregulation of cancer-relevant genes and binding with several MLL fusion partners. In yeast, Dot1-mediated H3K79 methylation is associated with telomere silencing, meiotic checkpoint control, and DNA damage response. View All» Species Reactivity: Human View All» Species Reactivity Note: Human. Not tested in other species. View All» Application Notes: ELISA: This antibody was reported by an outside laboratory to be suitable for ELISA AT A 1:1,000 dilution. View All» Quality Assurance: Immunocytochemistry:Gastric mucosal tissue incubated with anti-DOT1L stained strongly positive on nuclei. View All» Purification Method: Protein G chromatography View All» Presentation: Purified polyclonal antibody supplied in PBS with 0.09% sodium azide. View All» Storage Conditions: Stable for 6 months at 2-8°C from date of receipt. For long term storage, store at -20ºC. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q8TEK3 View All» Entrez Gene Number: NP_115871 View All» Gene Symbol:

• DOT1L

• DOT1

• KMT4
  View All» Alternate Names: DOT1-like protein DOT1-like, histone H3 methyltransferaseDOT1-like, histone H3 methyltransferase (S. cerevisiae)Histone H3-K79 methyltransferaseLysine N-methyltransferase 4histone methyltransferase DOT1L View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunocytochemistry

  • ELISA
    View All» UniProt Summary: FUNCTION: Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.CATALYTIC ACTIVITY: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine. Ref.1SUBCELLULAR LOCATION: NucleusProbable.MISCELLANEOUS: In contrast to other lysine histone methyltransferase, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.SEQUENCE SIMILARITIES: Belongs to the DOT1 family.SEQUENCE CAUTION: The sequence AAC08316.1 differs from that shown. Reason: Erroneous gene model prediction. View All» Product Name: Anti-DOT1L View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://www.16ao.com/thread-130364.htm
    © Merck Millipore代理07-2066 DOT1L Antibody (C-Terminus);已停产，产品报价联系微信jinshanbio