货号：07-2101

品牌：Merck Millipore

规格：

目录价：￥3968.00

市场价格：￥3372.80

会员价格：￥3174.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho PIX (Ser340) View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes PIX phosphorylated at Ser340. View All» Molecular Weight: ~ 75 kDa View All» Epitope: Phosphorylated Ser340 View All» Immunogen: KLH-conjugated linear peptide corresponding to mouse PIX phosphorylated at Ser340. View All» Modifications: Phosphorylation View All» Isotype: IgG View All» Background Information: p-21-activated kinase (PAK) interacting exchange factor (PIX) is a guanine nucleotide exchange factor. PIX is a necessary component for the recruitment, regulation and activation of Rac1, as it is able to directly bind Rac1 via its SH3 domain. Studies indicate that PIX may also have an active role as a positive regulator of apoptosis, an inducer of membrane ruffling and in cell migration. Along with Rac1, PIX has been shown to regulate and interact with GIT1 and NOD2. Alternative splicing and initiation give rise to 8 known isoforms. Expression of PIX has been localized to the central nervous system. Isoforms B, C and E have highest expression in the testis and brain. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with mouse. Predicted to react with human and rat based on 100% sequence homology. View All» Control: PIX transfected cell lysates View All» Quality Assurance: Evaluated by Western Blot in PIX transfected cell lysates.Western Blot Analysis: A 1:1000 dilution of this antibody detected PIX on 10 µg of Pix transfected cell lysates. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide, 1 mg/mL BSA and 30% glycerol. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: Q9ES28 View All» Entrez Gene Number: NP_001106989 View All» Gene Symbol:

• PIXB

• COOL1

• P50BP

• BETA-PIX

• p85

• PAK3

• Beta-Pix

• P85COOL1

• COOL-1

• P85

• PAK3BP

• P50
  View All» Alternate Names:
  • Rho guanine nucleotide exchange factor (GEF) 7

  • PAK-interacting exchange factor beta

  • guanine nucleotide exchange factor 7

  • rho guanine nucleotide exchange factor 7

  • SH3 domain-containing proline-rich protein

  • p85

  • PAK3

  • Beta-Pix

  • P85COOL1

  • COOL-1

  • P85

  • PAK3BP

  • P50
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. May function as a positive regulator of apoptosis. May function in cell migration (by similarity).SUBUNIT STRUCTURE: Interacts with PAK kinases through the SH3 domain. Interacts with unphosphorylated PAK1. Interacts with ITCH. Interacts with SCRIB; interaction is direct and may play a role in regulation of apoptosis by similarity. Interacts with GIT1 and TGFB1I1. Interacts with FRMPD4 (via N-terminus) (by similarity). TISSUE SPECIFICITY: Seems to be expressed in the central nervous system. Isoform B, isoform C and isoform E are expressed with highest levels in brain and testis. SEQUENCE SIMILARITIES: Contains 1 CH (calponin-homology) domain.Contains 1 DH (DBL-homology) domain.Contains 1 PH domain.Contains 1 SH3 domain. View All» Product Name: Anti-phospho PIX (Ser340) View All» Concentration: 0.02777 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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