货号：07-2112

品牌：Merck Millipore

规格：

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-FGFR-4 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes FGFR-4. View All» Molecular Weight: Approximately 115/125 kDa View All» Epitope: Unknown View All» Immunogen: KLH conjugated linear peptide selected from residues corresponding to human FGFR-4. View All» Background Information: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Reacts with mouse and rat. 100% homology with human based on sequence homology. View All» Control: Mouse lung tissue lysate View All» Quality Assurance: Evaluated by Western Blot in mouse lung tissue lysate.Western Blot Analysis: A 1:1000 dilution of this antibody detected FGFR4 on mouse lung tissue lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit serum in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C for up to 12 months. View All» UniProt Number: P22455 View All» Entrez Gene Number: Q03142 View All» Gene Symbol:
  • CD334

  • EC 2.7.10.1

  • FGFR-4

  • JTK2

  • MGC20292

  • OTTHUMP00000161430

  • TKF
    View All» Alternate Names:
    • CD334 antigen

    • fibroblast growth factor receptor 4

    • hydroxyaryl-protein kinase

    • protein-tyrosine kinase

    • tyrosine kinase related to fibroblast growth factorreceptor

    • tyrosylprotein kinase
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Receptor for acidic fibroblast growth factor. Does not bind to basic fibroblast growth factor. Binds FGF19.CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SUBUNIT STRUCTURE: Interacts with KLB By similarity.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Note: Isoform 2 may be secreted. TISSUE SPECIFICITY: Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines. PTM: Glycosylated By similarity. Phosphorylated on tyrosine residue By similarity. Phosphorylation requires the presence of a functional (phosphorylated) FGFR1 and not necessarily by means of FGFR heterodimerization By similarity.SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.Contains 3 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 protein kinase domain. View All» Product Name: Anti-FGFR-4 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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