货号：MAB1961Z

品牌：Merck Millipore

规格：100Ug

目录价：￥5831.00

市场价格：￥4956.35

会员价格：￥4664.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Integrin αVβ5 Antibody, clone P1F6, azide free | MAB1961Z View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with the human integrin alphaVbeta5. View All» Immunogen: Human UCLA P3 cells (lung carcinoma) View All» Clone: P1F6 View All» Isotype: IgG1 View All» Background Information: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha V chain. Alpha chain V undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. View All» Species Reactivity:

• Chicken

• Human
  View All» Application Notes: Inhibition of attachment of HT29 cells to vitronectin: >1:1,000 Inhibition of attachment of carcinoma and melanoma cells to vitronectin Immunohistochemistry: for use on acetone or paraformaldehyde fixed tissue. (Staining of formalin-fixed tissues REQUIRES boiling tissue sections in 1mM EDTA, pH 8.0, for 10-20 min followed by cooling at RT for 20 min.) Immunocytochemistry: for use on human carcinomas, normal epithelium and keratinocytes 1:1500 (Acetone Fixed Only) Immunoprecipitation FACS EIA Optimal working dilutions must be determined by the end user. View All» Applications Not Recommended: Immunohistochemistry (Paraffin) View All» Control: Epithelium, keratinocytes View All» Purification Method: Protein A purfied View All» Presentation: Purified immunoglobulin in 0.01M phosphate buffer, pH 7.1, 0.15M NaCl containing no preservatives. View All» Storage Conditions: Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P06756 View All» Entrez Gene Number: NM_002210.2 View All» Gene Symbol:
  • ITGAV

  • DKFZp686A08142

  • MSK8

  • CD51

  • VNRA
    View All» Alternate Names: MAB1961 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Immunohistochemistry

    • Affects Function
      View All» Entrez Gene Summary: ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. View All» UniProt Summary: FUNCTION: SwissProt: P06756 # The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.SIZE: 1048 amino acids; 116038 Da SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.SIMILARITY: SwissProt: P06756 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-Integrin αVβ5 Antibody, clone P1F6, azide free | MAB1961Z View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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      © Merck Millipore代理MAB1961Z Anti-Integrin αVβ5 Antibody, clone P1F6, azide free;抗整合素αVβ 5抗体，克隆P1F6，无叠氮化物store at +2℃ to +8℃，产品报价联系微信jinshanbio