货号：07-2117

品牌：Merck Millipore

规格：EA

目录价：￥3108.00

市场价格：￥2641.80

会员价格：￥2486.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-RSK1/2 (Ser363) (Turn motif) View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes RSK1/2 phosphorylated at (Ser363). View All» Molecular Weight: ~80 kDa observed View All» Epitope: Phosphorylated Ser363 of the AGC-kinase C-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to human RSK1/2 phosphorylated at (Ser363). View All» Background Information: P90 ribosomal S6 kinase 1 and 2 (RSK1 and RSK2) belong to a family of Ser/Thr kinases that are important for cell cycle, survival, proliferation and other cellular functions. RSK isoforms are made up of two kinase domains and seem to be activated sequentially by a number of phosphorylation events. RSK1 and RSK2 have both been found to be over-expressed in certain cancer types and both could be promising as cancer treatments. RSK2 has recently been implicated in oncogenesis and tumor progression. RSK1 interacts with PKARIalpha through the N-terminal kinase domain and regulates protein kinase A. View All» Species Reactivity:

• Human

• Xenopus
  View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Zebra Fish and Xenopus based on 100% sequence homology. View All» Control: EGF treated A431 cell lysate View All» Quality Assurance: Evaluated by Western Blot in EGF treated A431 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected RSK1/2 on 10 µg of EGF treated A431 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q15418 View All» Entrez Gene Number: NP_001006666 View All» Gene Symbol:
  • RPS6KA1

  • MAPKAPK1A

  • RSK1
    View All» Alternate Names:
    • Ribosomal protein S6 kinase alpha-1

    • S6K-alpha-1

    • 90 kDa ribosomal protein S6 kinase 1

    • p90-RSK 1

    • p90RSK1

    • p90S6K

    • MAP kinase-activated protein kinase 1a

    • MAPK-activated protein kinase 1a

    • MAPKAP kinase 1a

    • MAPKAPK-1a

    • Ribosomal S6 kinase 1

    • RSK-1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signaling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.COFACTOR: Magnesium.ENZYME REGULATION: Activated by multiple phosphorylations on threonine and serine residues. SUBUNIT STRUCTURE: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation.PTM: Autophosphorylated on Ser-380, as part of the activation process. SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 2 protein kinase domains. View All» Product Name: Anti-phospho-RSK1/2 (Ser363) (Turn motif) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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