货号：07-2119

品牌：Merck Millipore

规格：100Ug

目录价：￥4363.00

市场价格：￥3708.55

会员价格：￥3490.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-RalA Antibody (Ser194) | Cat. No. 07-2119 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes RalA phosphorylated at Ser194. View All» Molecular Weight: ~25 kDa observed. Uncharacterized bands may be observed at ~20 kDa, 100 kDa, and 130-170 kDa in some cell lysates. View All» Epitope: 0 View All» Immunogen: KLH-conjugated linear peptide corresponding to human RalA phosphorylated at Ser194. View All» Background Information: RalA and RalB are Ras-family small monomeric GTPases that can be activated through a Ras-dependent mechanism. The two are highly homologous (89%). Ral proteins are proximal effectors of oncogenic Ras and their activity is needed to support tumorigenesis in certain cancers. Mutants of Ras that are defective in activating all known Ras effectors except Ral GEF are still able to induce invasive phenotypes in transfected cells, suggesting a role for Ral in these processes. RalA is required for anchorage-independent proliferation and tumorigeneisis by driving exocyst assembly and polarized exocytosis in epithelial cells. View All» Species Reactivity:

• Human

• Bovine

• Rat

• Xenopus

• Zebrafish
  View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Bovine, Rat, Xenopus, and Zebrafish based on 100% sequence homology. View All» Application Notes: Western Blot Analysis: A representative lot detected phospho-RalA (Ser194) in certain primary and metastatic cell lysates, and in certain unmatched tumor tissue lysate samples. View All» Control: PANC10.05 cell lysate View All» Quality Assurance: Evaluated by Western Blot in PANC10.05 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected phospho-RalA in PANC10.05 cell lysate. Peptide inhibition was observed with the addition of phospho peptides but not with the addition of non-phospho peptides. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P11233 View All» Entrez Gene Number: NP_005393 View All» Gene Symbol:
  • RALA

  • Ral
    View All» Alternate Names: Ras-related protein Ral-A View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Peptide Inhibition Assay
      View All» Product Name: Anti-phospho-RalA (Ser194) View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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