货号：07-2129

品牌：Merck Millipore

规格：

目录价：￥4503.00

市场价格：￥3827.55

会员价格：￥3602.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-Abi-1 (Ser225) View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Abi-1 phosphorylated at Ser225. View All» Molecular Weight: ~60 kDa observed. 55 kDa calculated. View All» Epitope: Phosphorylated Ser225 View All» Immunogen: KLH-conjugated linear peptide corresponding to human Abi-1 phosphorylated at Ser225. View All» Modifications: Phosphorylation View All» Background Information: Abl interactor 1 (Abelson interactor 1) is a member of the family of Abl-interactors and is highly expressed in the brain. Abl interactor 1 is involved in the signaling of ABL1 and ABL2 nonreceptor tyrosine kinases, and the EGF-receptor. The Abl interactor 1 protein contains SH3 domains, and may function as an adaptor protein; It forms a trimeric complex with EPS8 and SOS1 in the transduction of signals from Ras to Rac. Previous studies have suggested that Abl interactor 1 via the Ras and Rac pathways may regulate cell proliferation, cell adhesion, and actin remodeling. Abl interactor 1 is also investigated for its role in tumor suppression. View All» Species Reactivity:

• Monkey

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Monkey and Human. Predicted to react with Mouse and Rat based on 100% sequence homology. View All» Application Notes: Western Blot Analysis: A representative lot was used by an independent laboratory in human mammary cells treated with EGF and Abi-1-transfected 293T cells (Mendoza, M., et al. (2011). Molecular Cell 41:661–671). View All» Control: EGF-treated COS cells untreated and treated with lambda phosphatase. View All» Quality Assurance: Evaluated by Western Blot in EGF-treated COS cells untreated and treated with lambda phosphatase.Western Blot Analysis: 1 µg/mL of this antibody detected Abi-1 in 10 µg of EGF-treated COS cells untreated and treated with lambda phosphatase. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q8IZP0 View All» Entrez Gene Number: NP_001012768 View All» Gene Symbol:
  • ABI1

  • SSH3BP1
    View All» Alternate Names:
    • Abl interactor 1

    • Abelson interactor 1

    • Abi-1

    • Abl-binding protein 4

    • AblBP4

    • Eps8 SH3 domain-binding protein

    • Eps8-binding protein

    • Nap1-binding protein

    • Nap1BP

    • Spectrin SH3 domain-binding protein 1

    • e3B1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene has been found to form a complex with EPS8 and SOS1, and is thought to be involved in the transduction of signals from Ras to Rac. In addition, the encoded protein may play a role in the regulation of EGF-induced Erk pathway activation as well as cytoskeletal reorganization and EGFR signaling. Several transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level (By similarity). SUBUNIT STRUCTURE: Interacts with ABL1, ENAH, STX1A, SNAP25, VAMP2, EPS8, and through its N-terminus with WASF1. Part of a complex consisting of ABI1, STX1A and SNAP25. Part of a complex consisting of ABI1, EPS8 and SOS1 (By similarity). Interacts with SOS1, SOS2, GRB2, SPTA1 and the first SH3 domain of NCK1. Isoform 6 does not interact with NCK1. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. SUBCELLULAR LOCATION: Cytoplasm By similarity. Nucleus (By similarity). Cell projection › lamellipodium (By similarity). Cell projection › filopodium (By similarity). Cell projection › growth cone (By similarity). Cell junction › synapse › synaptosome (By similarity). Cytoplasm › cytoskeleton (By similarity). Note: Localized to protruding lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes (By similarity). TISSUE SPECIFICTY: Widely expressed, with highest expression in brain. DOMAIN: The t-SNARE coiled-coil homology domain is necessary and sufficient for interaction with STX1A (By similarity).PTM: In vitro substrate for v-Abl (By similarity). Phosphorylated on tyrosine residues after serum stimulation or induction by v-Abl. INVOLVEMENT IN DISEASE: Note=A chromosomal aberration involving ABI1 is a cause of acute leukemias. Translocation t(10;11)(p11.2;q23) with MLL. ABI1 isoform 2 was found to be present in acute leukemia MLL-ABI1 fusion transcript.SEQUENCE SIMILARITIES: Belongs to the ABI family.Contains 1 SH3 domain.Contains 1 t-SNARE coiled-coil homology domain. View All» Product Name: Anti-phospho-Abi-1 (Ser225) View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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