货号：MAB1973

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Integrin α1 Antibody, clone FB12 | MAB1973 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with the I domain (Val151 - Ala364) of human alpha-1 integrin (CD49a)1. Precipitates proteins of Mr 180 kDa, pI 5.9-6.0 (alpha chain) and Mr 115 kDa, pI 4.5-5.0 (beta chain) from human lymphocyte lysates (Zocchi et al., 1991). View All» Molecular Weight: 130 kDa View All» Clone: FB12 View All» Isotype: IgG1 View All» Species Reactivity: Human View All» Application Notes: Immunohistochemistry: 2 μg/mL, with paraformaldehyde fixation.Immunohistochemistry: Frozen sections (7 µm) of placental tissue fixed with acetone for 1 hr. Antibody used at 1:10 dilution (Sato et al., 2003).Immunocytochemistry: iolated EVT cells firxed with 0.5% PFA @ 4°C for 15 minutes followed by acetone at -20°C for 2 minutes. Antibody was used at 1:10 dilution (Sato et al., 2003).Immunoblotting: 2 μg/mL Immunoprecipitation: 1 μg/mL FACS analysis: 2μg/mL (Sato et al., 2005).ELISA: 0.5 μg/mL Inhibition of activated human lymphocyte binding to laminin, collagen IV and fibronectin (Fabbri et al., 1996): 1-5 μg/mL Optimal working dilutions must be determined by end user. View All» Control: Microvascular endothelium View All» Purification Method: Protein A purfied View All» Presentation: Purified immunoglobulin in 0.02M PB, pH 7.6, 0.25M NaCl containing 0.1% sodium azide. View All» Storage Conditions: Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P56199 View All» Entrez Gene Number: NM_181501.1 View All» Gene Symbol:

• ITGA1

• CD49a

• VLA1

• VLA-1
  View All» Alternate Names: CD49a View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Flow Cytometry

  • Immunocytochemistry

  • Immunohistochemistry

  • Immunoprecipitation

  • Affects Function

  • Western Blotting
    View All» Entrez Gene Summary: This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. View All» UniProt Summary: FUNCTION: SwissProt: P56199 # Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G- E-R in collagen.SIZE: 1179 amino acids; 130848 Da SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-1 associates with beta-1.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.DOMAIN: SwissProt: P56199 The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.SIMILARITY: Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. & Contains 1 VWFA domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Integrin α1 Antibody, clone FB12 | MAB1973 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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