货号：MAB1980

品牌：Merck Millipore

规格：

目录价：￥4563.00

市场价格：￥3878.55

会员价格：￥3650.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Integrin αV Antibody, clone M9 | MAB1980 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Directed against integrin alphaV (CD51), MW 25 and 125 kDa in reduced and 150 kDa in unreduced from. It can form distinct complexes with beta 3 chain (CD61), integrin beta5 and integrin beta1 (CD29) subunits. CD51, in combination with CD61, is expressed on human platelets. It is also expressed on human monocytes and macrophages when CD51 is combined with beta 5 integrin. Platelet adhesion to vitronectin is inhibited by CD51. View All» Immunogen: Human melanoma cells View All» Clone: M9 View All» Isotype: IgG1 View All» Species Reactivity: Human View All» Application Notes: Use in functional studies on cells, indirect immunofluorescence staining with analysis by FACS or fluorescence microscopy. Optimal working dilutions must be determined by end user. View All» Control: HT-29 colon carcinoma cells Skin (Basement Membrane) View All» Purification Method: Protein A purfied View All» Presentation: Liquid in 20 mM TRIS buffer, 150 mM NaCl, pH 8.0, containing 10 mg BSA and 0.1% (w/v) sodium azide. View All» Storage Conditions: Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P06756 View All» Entrez Gene Number: NM_002210.2 View All» Gene Symbol:

• ITGAV

• DKFZp686A08142

• MSK8

• CD51

• VNRA
  View All» Alternate Names: CD51; VNR-alpha chain View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Flow Cytometry

  • Immunohistochemistry

  • Affects Function
    View All» Entrez Gene Summary: ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. View All» UniProt Summary: FUNCTION: SwissProt: P06756 # The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.SIZE: 1048 amino acids; 116038 Da SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.SIMILARITY: SwissProt: P06756 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-Integrin αV Antibody, clone M9 | MAB1980 View All» Concentration: 0.2 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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