货号：07-2160

品牌：Merck Millipore

规格：

目录价：￥3522.00

市场价格：￥2993.70

会员价格：￥2817.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TRB-3 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes TRB-3 corresponding to the N-terminus. View All» Molecular Weight: ~42 kDa observed View All» Epitope: N-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to the N-terminus of human TRB-3. View All» Background Information: Tribbles homolog 3 (TRB-3) is also known as SINK and is thought to play a role in a negative-feedback regulation pathway of NF-kappaB-inducible expression. TRB-3 seems to regulate the level and preciseness of MAPK kinase activation of MAPK. TRB-3 has been found to decrease cell-cycle progression and expression is up-regulated in response to stress. TRB-3 works by blocking Akt activation which inhibits insulin signaling and may play a role in the development of non-alcoholic fatty liver disease (NAFLD). View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with orangutan based on 100% sequence homology. View All» Control: HT-29 cell lysate View All» Quality Assurance: Evaluated by Western Blot in HT-29 cell lysate.Western Blot Analysis: 0.1 µg/mL of this antibody detected TRB-3 on 10 µg of HT-29 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q96RU7 View All» Entrez Gene Number: NP_066981 View All» Gene Symbol:

• TRB3

• TRB-3

• TRIB3

• SKIP3

• NIPK

• SINK
  View All» Alternate Names:
  • tribbles homolog 3 (Drosophila)

  • chromosome 20 open reading frame 97

  • Neuronal cell death-inducible putative kinase

  • p65-interacting inhibitor of NF-kappa-B

  • tribbles homolog 3

  • p65-interacting inhibitor of NF-kappaB

  • neuronal cell death inducible putative kinase
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Summary: The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity.SUBUNIT STRUCTURE: Interacts with AKT1, AKT2, ATF4, MAP2K1 and MAP2K7.SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Highest expression in liver, pancreas, peripheral blood leukocytes and bone marrow. Also highly expressed in a number of primary lung, colon and breast tumors. Expressed in spleen, thymus, and prostate and is undetectable in other examined tissues, including testis, ovary, small intestine, colon, leukocyte, heart, brain, placenta, lung, skeletal muscle, and kidney.INDUCTION: By hypoxia, TNF and by nutrient starvation. Expression is PI 3-kinase and/or NF-kappa-B-dependent.SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily. Contains 1 protein kinase domain.CAUTION: The role of this protein in Akt activation has been demonstrated by Du et al (PubMed:12791994) for the mouse ortholog but Iynedjian (PubMed:15469416) has not been able to reproduce the result in rat hepatocytes. View All» Product Name: Anti-TRB-3 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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