货号：07-2170

品牌：Merck Millipore

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目录价：￥3522.00

市场价格：￥2993.70

会员价格：￥2817.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PI3 Kinase-C2β View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: 0 View All» Molecular Weight: ~184 kDa observed. Weaker cross-reacting bands observed at ~28 and 16 kDa in some lysates. View All» Epitope: 0 View All» Immunogen: KLH-conjugated linear peptide corresponding to human PI3 Kinase-C2β. View All» Background Information: The class II phosphoinositide 3-kinase beta (PI3K-C2) is a member of the PI3K family of enzymes and is thought to play a role in the creation of 3’ phosphoinositides after the activation of polypeptide growth factor receptors. PI3K-C2activation during liver growth causes increased levels of phosphatidylinositol 4-phosphate in cell nuclei and may be regulated by calpain. The proline-rich motifs in the N-terminus of PI3K-C2 is thought to associate with epidermal growth factor and this could also include the Grb2 adaptor. It has also been shown that PI3K-C2 may play a role in a signaling pathway for cell migration. Recent research has also found that PI3K-C2 may be essential in T-cell activation. View All» Species Reactivity:

• Human

• Chimpanzee

• Rhesus Macaque
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with chimpanzee, rhesus macaque, and orangutan based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: 1:300 dilution from a previous lot was used to detect PI3K-C2β in normal human spleen tissue. View All» Control: MCF-7 cell lysate View All» Quality Assurance: Evaluated by Western Blot in MCF-7 cell lysate.Western Blot Analysis: 2 µg/mL of this antibody detected PI3 Kinase-C2β on 10 µg of MCF-7 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O00750 View All» Entrez Gene Number: NP_002637.3 View All» Gene Symbol:
  • C2-PI3K

  • PIK3C2B
    View All» Alternate Names:
    • phosphoinositide-3-kinase, class 2, beta polypeptide1 2 phosphatidylinositol 3-kinase C2 domain-containing beta polypeptide

    • PI3K-C2beta

    • PTDINS-3-kinase C2 beta

    • Phosphoinositide 3-kinase-C2-beta

    • phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta

    • PtdIns-3-kinase C2 subunit beta

    • PI3K-C2-beta
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» Entrez Gene Summary: The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades. Ref.4CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.CAFACTOR: Calcium, magnesium, or manganese. ENZYME REGULATION: Activated by GRB2. SUBUNIT STRUCTURE: Part of a complex with ERBB2 and EGFR. Part of a complex with phosphorylated EGFR and GRB2. Interacts with phosphorylated EGFR and PDGFR, maybe indirectly. Interacts with GRB2 and SHC1. SUBCELLULAR LOCATION: Microsome. Cell membrane. Cytoplasm › cytosol. Nucleus. Endoplasmic reticulum. Note: Found mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis. TISSUE SPECIFICITY: Expressed in columnar and transitional epithelia, mononuclear cells, and ganglion cells (at protein level). Widely expressed, with highest levels in thymus and placenta and lowest in peripheral blood, skeletal muscle and kidney. SEQUENCE SIMILARITIES: Belongs to the PI3/PI4-kinase family.Contains 1 C2 domain.Contains 1 PI3K/PI4K domain.Contains 1 PX (phox homology) domain.CAUTION: It is uncertain whether Met-1 or Met-26 is the initiator.SEQUENCE CAUTION: The sequence CAA74194.1 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-PI3 Kinase-C2β View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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