货号：MAB2007

品牌：Merck Millipore

规格：

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Plakophilin-3, amino acids 570-589, clone 92623E3/4 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with plakophilin-3 View All» Epitope: amino acids 570-589 View All» Immunogen: Synthetic peptide corresponding to amino acids 570-589 of human plakophilin-3 protein coupled to KLH. View All» Clone: 92623E3/4 View All» Isotype: IgG2b View All» Background Information: Plakophilin-3 is an Armadillo-like protein present in nuclei and desmosomes of epithelial cells. The expression pattern of this protein seems to be largely restricted to epithelial cell types. Plakophilin-3 can be detected along cell borders in a punctuate staining pattern typical for desmosomal proteins. In addition to the desmosomal immunolocalization, immunostaining was observed as bright nuclear speckles. Thus, like plakophilin-1 and-2, plakophilin-3 displays a dual intracellular localization in the desmosomal plaque and in the cell nucleus, and therefore is probably involved in signal transduction pathways between the plasma membrane and the nucleus. The human protein has a predicted molecular weight of 87 kDa. View All» Species Reactivity:

• Canine

• Human

• Mouse
  View All» Application Notes: Western blot: 1:100 - 1:1000 Immunohistochemistry: Frozen or paraffin-embedded tissue sections. 1:25 - 1:200 with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent Immunocytochemistry: Methanol and paraformaldehyde-fixed cells For optimal results, fixed cells and frozen tissues should be treated with 0.2% Triton-X 100 for 5 min and 15 min, respectively, prior to incubation with primary antibody. View All» Presentation: Purified immuoglobulin. Liquid in PBS containing 0.09% sodium azide. View All» Storage Conditions: 1 year at 4°C from date of shipment View All» UniProt Number: Q9Y446 View All» Entrez Gene Number: NM_007183.2 View All» Gene Symbol:
  • PKP3

  • Plakophilin-3.
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting

    • Immunocytochemistry

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways. View All» UniProt Summary: FUNCTION: SwissProt: Q9Y446 # May play a role in junctional plaques.SIZE: 797 amino acids; 87082 Da SUBCELLULAR LOCATION: Nucleus. Cell junction, desmosome. Note=Nuclear and associated with desmosomes.TISSUE SPECIFICITY: Found in desmosomes of most simple and stratified epithelia. Not found in foreskin fibroblasts and various sarcoma-derived cell lines. Beside dendritic reticular cells of lymphatic follicles not found in non-epithelial desmosome-bearing tissues.SIMILARITY: SwissProt: Q9Y446 ## Belongs to the beta-catenin family. & Contains 8 ARM repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-Plakophilin-3, amino acids 570-589, clone 92623E3/4 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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