货号：MAB2010

品牌：Merck Millipore

规格：100UL

目录价：￥3132.00

市场价格：￥2662.20

会员价格：￥2505.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cartilage Proteoglycan Antibody, fetal, clone HFPG-846 | MAB2010 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes a protein-related eptiope on the chondroitin sulfate-attachment region of native fetal human articular cartilage proteoglycan. Does not react with chondroitinase or hyaluronidase digested fetal human cartilage aggrecan. Cross-reactive with both fetal and adult aggrecans of other species. Fetal specificity is only demonstrated in the human system. View All» Epitope: fetal View All» Immunogen: Native fetal human cartilage aggrecan. View All» Clone: HFPG-846 View All» Isotype: IgM View All» Species Reactivity: Human View All» Application Notes: Western Blot at 1:100-1:400. ELISA at 1:1,000 - 1:4,000. RIA at 1:200 - 1:4,000. Immunohistochemistry (unfixed only) at 1:2 - 1:5. Final working dilutions must be determined by end user. View All» Presentation: Ascites fluid. View All» Storage Conditions: Maintain at -20°C in aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P16112 View All» Entrez Gene Number:

• NM_001135.2

• NM_013227.2
  View All» Gene Symbol:
  • ACAN

  • MSK16

  • SEDK

  • CSPCP

  • AGCAN

  • AGC1

  • CSPG1

  • CSPGCP
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Radioimmunoassay

    • Western Blotting

    • Immunohistochemistry
      View All» Entrez Gene Summary: This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. View All» UniProt Summary: FUNCTION: SwissProt: P16112 # This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.SIZE: 2415 amino acids; 250193 Da SUBUNIT: Interacts with FBLN1 (By similarity).SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).TISSUE SPECIFICITY: Restricted to cartilages.DEVELOPMENTAL STAGE: Expression was detected in chondrocytes throughout the developing skeleton.DOMAIN: SwissProt: P16112 Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3.PTM: Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase.DISEASE: SwissProt: P16112 # Defects in AGC1 are the cause of spondyloepiphyseal dysplasia type Kimberley (SEDK) [MIM:608361]. Spondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy.SIMILARITY: Belongs to the aggrecan/versican proteoglycan family. & Contains 1 C-type lectin domain. & Contains 1 EGF-like domain. & Contains 1 Ig-like V-type (immunoglobulin-like) domain. & Contains 4 Link domains. & Contains 1 Sushi (CCP/SCR) domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Cartilage Proteoglycan Antibody, fetal, clone HFPG-846 | MAB2010 View All» Concentration: 62 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Ascites View All» Host: Mouse View All»
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