货号：07-2189

品牌：Merck Millipore

规格：

目录价：￥3847.00

市场价格：￥3269.95

会员价格：￥3077.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CAPZIP View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~70 kDa observed. The native form of CAPZIP runs anomalously, with a molecular mass of 70 kDa (much slower than its real molecular mass). The 47 kDa band may be non-specific, a splice variant or a degradation product. (Eyers, C.E., et al. (2005). Biochem J. 389(1):127-135.). An uncharacterized band appears at ~18 kDa. View All» Epitope: 0 View All» Immunogen: GST-tagged recombinant protein corresponding to human CAPZIP. View All» Background Information: CAPZIP (CapZ-interacting protein) is highly expressed in immune cells and muscle and uniquely interacts with CapZ, an F-actin capping protein, in splenocytes. Phosphorylation of CAPZIP is thought to regulate CapZ ability to remodel actin filament assembly. CAPZIP may also contain a CPI (capping protein interaction) motif that seems to restrict capping protein to a low-affinity, filament-binding conformation. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. Other homologies: Mouse (64% sequence homology). Rat (58% sequence homology). View All» Application Notes: Immunoprecipitation Analysis: 10 µg from a previous lot immunoprecipitated CAPZIP from Jurkat cell lysate. View All» Control: Jurkat cell lysate View All» Quality Assurance: Evaluated by Western Blot in Jurkat cell lysate.Western Blot Analysis: 1:250 dilution of this antibody detected CAPZIP on 10 µg of Jurkat cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q6JBY9 View All» Entrez Gene Number: NP_443094 View All» Gene Symbol:

• MK2S4

• CAPZIP
  View All» Alternate Names:
  • RCSD domain containing 1

  • capZ-interacting protein

  • Protein kinase substrate CapZIP

  • protein kinase substrate MK2S4

  • RCSD domain-containing protein 1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunoprecipitation
      View All» UniProt Summary: FUNCTION: Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly.SUBUNIT STRUCTURE: Interacts with CAPZA2 and CAPZB. TISSUE SPECIFICITY: Highly expressed in skeletal muscle and more weakly in cardiac muscle. Also expressed in several lymphoid organs, including spleen, thymus, peripheral blood leukocytes, lymph node and bone marrow.POST-TRANSLATIONAL MODIFICATION: Dephosphorylation results in its dissociation from CAPZA2.SEQUENCE SIMILARITIES: Contains 1 RCSD domain.SEQUENCE CAUTION: The sequence CAB70910.1 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-CAPZIP View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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