货号：07-2197

品牌：Merck Millipore

规格：

目录价：￥3522.00

市场价格：￥2993.70

会员价格：￥2817.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PDE3A View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the C-terminus of cGMP-inhibited 3',5'-cyclic phosphodiesterase A. View All» Molecular Weight: ~125 kDa observed View All» Epitope: C-terminus View All» Immunogen: KLH conjugated linear peptide corresponding to the C-terminus of cGMP-inhibited 3',5'-cyclic phosphodiesterase A. View All» Background Information: Phosphodiesterase 3A (PDE3A) is an inotropic agent that has been used to treat congestive heart failure. In the pre-ovulatory follicle, it is thought to play a big role in oocyte meiotic resumption. PDE3A has been shown to be activated by PKB/Akt-mediated phosphorylation. Inhibiting PDE3A changes the cystic fibrosis transmembrane conductance regulator sub-mucosal gland secretion. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. Other homologies: Mouse (77% sequence homology). View All» Application Notes: Immunoprecipitation Analysis: 10 µg from a representative lot immunoprecipitated PDE3A from PMA treated HEK293 cell lysate. View All» Control: HEK293 SS cell lysate View All» Quality Assurance: Evaluated by Western Blot in HEK293 SS cell lysate.Western Blot Analysis: 0.1 µg/mL of this antibody detected PDE3A on 10 µg of HEK293 SS cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q14432 View All» Entrez Gene Number: NP_000912 View All» Gene Symbol: PDE3A View All» Alternate Names:

• cGMP-inhibited 3',5'-cyclic phosphodiesterase A

• Cyclic GMP-inhibited phosphodiesterase A

• CGI-PDE A
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunoprecipitation
    View All» UniProt Summary: FUNCTION: Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (By similarity).CATALYTIC ACTIVITY: Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.COFACTOR: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions (By similarity).ENZYME REGULATION: Inhibited by cGMP.SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein Potential. SEQUENCE SIMILARITIES: Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily. View All» Product Name: Anti-PDE3A View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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