货号：07-2261

品牌：Merck Millipore

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目录价：￥3522.00

市场价格：￥2993.70

会员价格：￥2817.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-WNK2 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~260 kDa observed. The Uniprot describes 4 isoforms produced by alternative splicing: 242, 234, 84 & 238. View All» Epitope: 0 View All» Immunogen: GST-tagged recombinant protein corresponding to human WNK2. View All» Background Information: WNK2 (with no K=lysine 2) is a serine/threonine protein kinase with catalytic domains that are 95% homologous to WNK1. WNK2 is thought to play a role in blood pressure homeostasis. WNK2 has been identified as a cell growth regulator that is thought to regulate ERK1/2 protein kinase activation. Specifically, WNK2 seems to regulate a RhoA-mediated cross-talk apparatus that controls how well MEK1 can activate ERK1/2 once the growth factor is excited. This control over cell proliferation has made WNK2 a potential target tumor suppressor. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. Other homologies: Mouse (87% sequence homology) and Rat (78% sequence homology). View All» Application Notes: Immunohistochemistry Analysis: 1:50 dilution from a previous lot detected WNK2 in human colon tissue. View All» Control: Human WNK2–FLAG (N-terminus) cell extract View All» Quality Assurance: Evaluated by Western Blot in human WNK2–FLAG (N-terminus) cell extract.Western Blot Analysis: 1 µg/mL of this antibody detected WNK2 on 10 µg of human WNK2–FLAG (N-terminus) cell extract. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide and 30% glycerol. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: Q9Y3S1 View All» Entrez Gene Number: NP_006639 View All» Gene Symbol:

• SDCCAG43

• PRK

• PRKWNK2

• NY-CO-43

• KIAA1760

• WNK2
  View All» Alternate Names:
  • WNK lysine deficient protein kinase 2

  • Serologically defined colon cancer antigen 43

  • P/OKcl.13

  • protein kinase, lysine deficient 2

  • mitogen-activated protein kinase kinase kinase

  • Protein kinase lysine-deficient 2

  • serine/threonine-protein kinase WNK2

  • Antigen NY-CO-43

  • Protein kinase with no lysine 2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: Summary: The protein encoded by this gene is a cytoplasmic serine-threonine kinase that contains cysteine in place of the lysine found at the conserved ATP-binding location in subdomain II of protein kinases. Since this protein does have kinase activity, it is possible that another lysine in the kinase subdomain I can substitute for the missing conserved lysine. [provided by RefSeq]. View All» UniProt Summary: CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.COFACTOR: Magnesium (by similarity).ENZYME REGULATION: Activation requires autophosphorylation of Ser-356. Phosphorylation of Ser-352 also promotes increased activity (by similarity).TISSUE SPECIFICITY: Predominantly expressed in heart, brain and colon.SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily. Contains 1 protein kinase domain.CAUTION: Cys-224 is present instead of the conserved Lys which is expected to be an active site residue. Lys-207 appears to fulfill the required catalytic function.SEQUENCE CAUTION: The sequence AAH37965.1 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-WNK2 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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