货号：07-2275

品牌：Merck Millipore

规格：

目录价：￥3264.00

市场价格：￥2774.40

会员价格：￥2611.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho GSK3β-(Ser389) View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes phosphorylated GSK3β (Ser389). View All» Molecular Weight: ~ 47 kDa View All» Epitope: Phosphorylated Ser389 View All» Immunogen: KLH-conjugated linear peptide corresponding to mouse GSK3β. View All» Isotype: IgG View All» Background Information: GSK3 (Glycogen Synthase Kinase 3) differs from most serine/threonine kinases in that it is active in the absence of the action of signaling pathways. Two isoforms exist, GSK3α and GSK3β. The function of GSK3 is to phosphorylate Glycogen Synthase and thereby inactivate it. Insulin action stimulates the PI3 Kinase pathway, resulting in Akt activation, which phosphorylates and inactivates GSK3. Glycogen Synthase is then rapidly dephosphorylated and activated. Other GSK3 substrates include Jun (on inhibitory sites), and eIF2B. Phosphorylation of Tau by GSK3 may relate to development of Alzheimer's disease. Phosphorylation state-specific antibodies directed against the Akt site (Ser21) on GSK3 are suitable for surrogate assays of the activation state of the pathway. View All» Species Reactivity:

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with mouse and rat. View All» Control: Mouse brain tissue lysate View All» Quality Assurance: Evaluated by Western Blot in mouse brain tissue lysate.Western Blot Analysis: 1:500 dilution of this antibody detected GSK3β on 10 µg of mouse brain tissue lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9WV60 View All» Entrez Gene Number: NP_062801 View All» Gene Symbol: GSK3B View All» Alternate Names:
  • glycogen synthase kinase 3 beta

  • GSK3beta isoform

  • GSK-3 beta
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. May phosphorylate MUC1 and decrease the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin by similarity.CATALYTIC ACTIVITY: ATP + [tau protein] = ADP + [tau protein] phosphate.SUBUNIT STRUCTURE: Monomer By similarity. Interacts with AXIN1, CABYR, MMP2, MUC1, NIN and PRUNE By similarity. Interacts with ARRB2.PTM: Phosphorylation on Tyr-216 is necessary for the activity By similarity.SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.Contains 1 protein kinase domain. View All» Product Name: Anti-phospho GSK3β-(Ser389) View All» Concentration: 0.06 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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