货号：07-2276

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-mSIN1 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes mSIN1. View All» Molecular Weight: Expected:59 kDa, Observed 61 kDa View All» Epitope: Unknown View All» Immunogen: KLH-conjugated linear peptide corresponding to human mSIN1. View All» Background Information: mSIN1 (mamalian stress-activated protein kinase (SAPK)-interacting protein 1, MAPKAP1) is an essential component of the Torc2 complex. mTORC2 is comprised of mTOR, a large Ser/Thr protein kinase along with SIN1, GbL (mLST8), Protor1, Protor2, and Rictor. The complex that is activated primarily downstream of PI3 Kinase is known to affect cell proliferation and survival primarily by phosphorylating Akt on Ser473. Additionally, the mTORC2 complex is also known to effect cytoskeletal organization and migration by exerting its effects through Rac, Rho, and PKC. SIN1 is also known to directly interact without proteins that include Ras, SPAKs, and JNK. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Reacts with human, mouse, and rat. View All» Control: C2C12 cell lysate View All» Quality Assurance: Evaluated by Western Blot in C2C12 cell lysate.Western Blot Analysis: A 1:1,000 of this antibody detected mSIN1 on 10 µg of C2C12 cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit serum in PBS with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9BPZ7 View All» Entrez Gene Number: NP_001006618.1 View All» Gene Symbol:
  • MAPKAP1

  • JC310

  • MIP1

  • SIN1

  • SIN1b

  • SIN1g
    View All» Alternate Names:
    • MEKK2-interacting protein 1

    • Mitogen-activated protein kinase 2-associated protein 1

    • SAPK-interacting protein 1

    • Stress-activated map kinase-interacting protein 1

    • TORC2 subunit MAPKAP1

    • mitogen-activated protein kinase associated protein 1

    • ras inhibitor MGC2745

    • stress-activated map kinase interacting protein 1

    • stress-activated protein kinase-interacting 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation
        View All» Entrez Gene Summary: This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. [provided by RefSeq] View All» UniProt Summary: FUNCTION: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. SUBUNIT STRUCTURE: Interacts with IFNAR2 By similarity. All isoforms except isoform 4 can be incorporated into the mammalian target of rapamycin complex 2 (mTORC2) which contains FRAP1, LST8, PROTOR1, RICTOR and MAPKAP1. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts with ATF2, MAP3K2 and MAPK8. Interacts with GTP-bound HRAS and KRAS.SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Nucleus. TISSUE SPECIFICITY: Ubiquitously expressed, with highest levels in heart and skeletal muscle. SEQUENCE SIMLARITIES: Belongs to the SIN1 family. View All» Product Name: Anti-mSIN1 View All» Concentration: 0.133 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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