货号：MAB2130

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ICAM-1 Antibody, clone W-CAM-1 | MAB2130 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: ICAM-1 belongs to the immunoglobulin superfamily, C2 subset. It is a transmembrane molecule of 90 kD with 7 potential N-glycosylation sites. It is expressed on resting monocytes and endothelial cells and can be upregulated on many other cells, e.g. with lymphokines, on B and T lymphocytes, thymocytes, dendritic cells, keratinocytes, chondrocytes, and epithelial cells. CD54 mediates cell adhesion binding to integrins CD11a/CD18 (LFA-1) and to CD11b/CD18 (Mac-1). The interaction of CD54 with LFA-1 enhances antigen-specific T cell activation. CD54 also binds to CD43 and to Plasmodium falciparum-infected erythrocytes. View All» Immunogen: RAJI cells View All» Clone: W-CAM-1 View All» Isotype: IgG View All» Species Reactivity: Human View All» Application Notes: Immunohistochemistry (formalin fixed, paraffin embedded tissues): 1:20 Flow cytometry on activated lymphocytes. Functional assays in adhesion research. Optimal working dilutions must be determined by the end user. View All» Control: POSITIVE CONTROL: MOLT-4, Raji, and Jurkat cells. View All» Presentation: Liquid containing sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to one year. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P05362 View All» Entrez Gene Number: NM_000201.1 View All» Gene Symbol:

• ICAM1

• P3.58

• BB2

• CD54

• ICAM-1
  View All» Alternate Names: CD54 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Flow Cytometry

  • Immunohistochemistry (Paraffin)
    View All» Entrez Gene Summary: ICAM1 (CD54) is typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. ICAM1 is also exploited by Rhinovirus as a receptor. View All» UniProt Summary: FUNCTION: SwissProt: P05362 # ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). In case of rhinovirus infection acts as a cellular receptor for the virus. Also acts as receptor for some coxsackieviruses.SIZE: 532 amino acids; 57825 Da SUBUNIT: Interacts with human herpesvirus 8 MIR2 protein (Probable).SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.PTM: Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.SIMILARITY: SwissProt: P05362 ## Belongs to the immunoglobulin superfamily. ICAM family. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. View All» Brand Family: Chemicon View All» Product Name: Anti-ICAM-1 Antibody, clone W-CAM-1 | MAB2130 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Ascites View All» Host: Mouse View All»
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