货号：MAB2143

品牌：Merck Millipore

规格：100Ug

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-VCAM-1 Antibody, clone B-N8 | MAB2143 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: B-N8 specifically recognizes human VCAM-1 [CD106] View All» Clone: B-N8 View All» Isotype: IgG1 View All» Species Reactivity: Human View All» Application Notes: Immunohistochemistry: 0.5 μg/mL on acetone-fixed cryostat sections. Flow cytometry: 1 μg per 10E6 cells (HUVEC) Function studies: B-N8 can be used in studies of cell adhesion molecules. ELISA Optimal working dilutions must be determined by the end user. View All» Presentation: > 95% purified immunoglobulin as determined by SDS-gel electrophoresis prior to addition of stabilizer and preservative. Liquid in PBS. View All» Storage Conditions: Maintain at +2-8°C upon date of receipt. For long-term storage, aliquot and store at -20°C. Avoid repeated Freeze/thaw cycles. View All» UniProt Number: P19320 View All» Entrez Gene Number:

• NM_001078.2

• NM_080682.1
  View All» Gene Symbol:
  • VCAM1

  • INCAM-100

  • MGC99561

  • CD106

  • DKFZp779G2333

  • L1CAM
    View All» Alternate Names: CD106 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Immunohistochemistry
      View All» Entrez Gene Summary: This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P19320 # Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.SIZE: 739 amino acids; 81276 Da SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.DOMAIN: SwissProt: P19320 Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.PTM: Sialoglycoprotein.DISEASE:SwissProt: P19320 # May play an important role in the genesis of atherosclerosis and rheumatoid arthritis.SIMILARITY: Contains 7 Ig-like C2-type (immunoglobulin-like) domains. View All» Brand Family: Chemicon View All» Product Name: Anti-VCAM-1 Antibody, clone B-N8 | MAB2143 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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