货号：MAB2152X

品牌：Merck Millipore

规格：

目录价：￥4385.00

市场价格：￥3727.25

会员价格：￥3508.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Endoglin Antibody, clone P3D1, Alexa Fluor® 488 conjugated | MAB2152X View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with human endoglin. View All» Immunogen: Human resting umbilical vein endothelial cells View All» Clone: P3D1 View All» Isotype: IgG2a View All» Background Information: Human endoglin (ancillaryTGF-beta receptor). Endoglin is a transmembrane glycoprotein expressed by vascular endothelial cells. It functions as an ancillary receptor influencing binding of the Transforming Growth Factor beta (TGF-beta) family ligands to signalling receptors. homodimeric integral membrane protein comprised of 95Kd subunits (CD105). CD105 is a component of the TGF-B receptor system and can bind TGF-B1 and TGF-B3 with high affinity but does not bind TGF-B2. CD105 is expressed by vascular endothelial cells and syncytiotrophoblasts of placenta and is weakly expressed by stromalfibroblasts. U937 cells and activated macrophages also expresses CD105. Expression of CD105 is increased on activated endothelium in tissues undergoing angiogenesis, ,such as in tumors, or in cases of wound healing or dermal inflammation. The epitope of clone P3D1 as well as the epitopes of several other endoglin clones is mapped in the this reference: Puchuantes, S et al (1997) Tissue Antigens 50(3):265-76. View All» Species Reactivity: Human View All» Application Notes: Immunocytochemistry: 2 μg/mL Flow cytometry: 0.2 μg per 1 x 10⁶ cells in 100 μL volume. Optimal working dilutions must be determined by the end user. View All» Presentation: Purified immunoglobulin conjugated to Alexa Fluor® 488. Liquid in PBS containing 1% BSA, 0.05% Tween®-20 and 0.05% sodium azide. View All» Storage Conditions: Maintain at 2°-8°C for up to 12 months from date of receipt. View All» UniProt Number: P17813 View All» Entrez Gene Number: NM_000118.1 View All» Gene Symbol:

• ENG

• ORW

• CD105

• HHT1

• END

• FLJ41744

• ORW1

• endoglin
  View All» Usage Statement:
  • Alexa Fluor® is a registered trademark of Molecular Probes, Inc.

  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    View All» Key Applications:
    • Flow Cytometry

    • Immunocytochemistry
      View All» Entrez Gene Summary: Endoglin is a homodimeric transmembrane glycoprotein highly expressed by endothelial cells. It is a component of the transforming growth factor beta receptor complex as it binds TGFB1 and TGFB3 with high affinity. Mutations in the endoglin gene produce hereditary hemorrhagic telangiectasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P17813 # Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.SIZE: 658 amino acids; 70578 Da SUBUNIT: Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGF-beta receptors I and/or II. It is able to bind TGF-beta 1, and 3 efficiently and TGF-beta 2 less efficiently.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Endoglin is restricted to endothelial cells in all tissues except bone marrow.DISEASE: SwissProt: P17813 # Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300, 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity. View All» Brand Family: Chemicon View All» Product Name: Anti-Endoglin Antibody, clone P3D1, Alexa Fluor® 488 conjugated | MAB2152X View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: AlexaFluor®488 View All» Host: Mouse View All»
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