货号：MAB2232

品牌：Merck Millipore

规格：EA

目录价：￥3708.00

市场价格：￥3151.80

会员价格：￥2966.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-GCAP1 Antibody, clone G2 | MAB2232 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes GCAP1. View All» Molecular Weight: ~ 23 kDa View All» Epitope: Unknown View All» Immunogen: GST-tagged GCAP1. View All» Clone: G2 View All» Isotype: IgG2aκ View All» Background Information: Guanylate cyclase-activating proteins (GCAPs) are calcium binding proteins that belong to the calmodulin super family. GCAPs without calcium are responsible for activation of photoreceptor guanylate cyclase during light adaptation. Studies have shown that the addition or subtraction of Ca2+ results in major conformational changes and the activation/deactivation of GCAP 1 and GCAP 2. It has been demonstrated that both GCAP 1 and 2 act on guanylate cyclase similarly and have approximately 50% homology between the two forms. GCAP 1 is predominantly localized in the photoreceptor outer segments. These results suggest that although GCAP1 is involved in the Ca2+-sensitive regulation of GC in rod and cone outer segments, GCAP2 may have non-phototransduction functions in photoreceptors and inner retinal neurons. View All» Species Reactivity:

• Bovine

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Bovine. Predicted to react with human, mouse and rat (1). Reactivity with other species has not been tested. View All» Application Notes: Immunohistochemistry: 1:2,000 on bovine retinal tissue (See Reference for more information.) View All» Control: Bovine Retina Lysate. View All» Quality Assurance: Western Blot Analysis: 1:2,000 dilution of this lot detected GCAP1 on 10 µg of Bovine Retina lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG2aқ in buffer containing 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3. View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt. View All» UniProt Number: P43080 View All» Entrez Gene Number: NP_000400.2 View All» Gene Symbol:
  • COD3

  • GCAP

  • GCAP1

  • GUCA

  • GUCA1

  • OTTHUMP00000016397

  • OTTHUMP00000196466
    View All» Alternate Names:
    • GCAP 1

    • Guanylate cyclase activator 1A

    • guanylate cyclase activator 1A (retina)
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» Entrez Gene Summary: This gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein encoded by this gene, guanylyl cyclase activating protein 1 (GCAP1), mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3); a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations; causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Stimulates guanylyl cyclase 1 (GC1) when free calcium ions concentration is low and inhibits GC1 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure.SUBCELLULAR LOCATION: Membrane; Lipid-anchor. TISSUE SPECIFICITY: Retina; cone outer and inner segments, in particular, in disk membrane regions, and to a lesser extent rod inner and outer segments.DISEASE: Defects in GUCA1A are the cause of cone dystrophy type 3 (COD3) [MIM:602093]. COD3 is an autosomal dominant cone dystrophy. Cone dystrophies are retinal dystrophies characterized by progressive degeneration of the cone photoreceptors with preservation of rod function, as indicated by electroretinogram. However, some rod involvement may be present in some cone dystrophies, particularly at late stage. Affected individuals suffer from photophobia, loss of visual acuity, color vision and central visual field. Another sign is the absence of macular lesions for many years. Cone dystrophies are distinguished from the cone-rod dystrophies, in which some loss of peripheral vision also occurs. Ref.4 Ref.5 Ref.6 Ref.7MISCELLANEOUS: Binds three calcium ions.SIMILARITY: Contains 4 EF-hand domains. View All» Product Name: Anti-GCAP1 Antibody, clone G2 | MAB2232 View All» Concentration: 1 mg/mL. View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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