货号：MAB2255

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Tropomyosin-3 Antibody, clone 3F8.2 | MAB2255 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~29 kDa observed View All» Immunogen: KLH-conjugated linear peptide corresponding to rat Tropomyosin-3. View All» Clone: 3F8.2 View All» Isotype: IgG1κ View All» Background Information: Tropomyosins (Tms) are a family of over 40 highly conserved protein isoforms that result from alternative splicing of four different genes during development and that are expressed in numerous cell types. These proteins form coiled-coil heterodimers which bind to actin polymers along the α-helical grove. Tropomyosin’s function varies depending on cell type in which it is expressed. Within muscle, Tms play a role in the regulation of actin-myosin interplay for the purpose of mediating muscle contraction. In non-muscle cells, studies suggest a role in the stabilization of actin filaments, along with protecting actin filaments from the severing action of gelsolin and ADF/cofilin depolymerization. Tms also appear to have a role in the moderation of access to actin for other actin-binding proteins. Tropomyosin has an integral role in maintaining cardiovascular homeostasis. Down-regulation of Tms expression has been observed in tumor cells indicating a possible role for Tms as tumor suppressors. View All» Species Reactivity:

• Mouse

• Human

• Rat
  View All» Species Reactivity Note: Demonstrated to react with human and mouse. Predicted to react with rat based on immunogen design. View All» Application Notes: Immunohistochemistry Analysis: 1:300 dilution of this antibody from a previous lot detected Tropomyosin-3 in human striated muscle tissue. View All» Control: Mouse brain tissue lysate View All» Quality Assurance: Evaluated by Western Blot in mouse brain tissue lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected Tropomyosin-3 on 10 µg of mouse brain tissue lysate. View All» Purification Method: Protein G View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q63610 View All» Entrez Gene Number: NP_476556 View All» Gene Symbol:
  • hscp30

  • TRK

  • NEM1

  • TM30

  • TM3

  • TM30nm

  • TM-5

  • hTM5

  • TPMsk3
    View All» Alternate Names:
    • tropomyosin 3

    • tropomyosin gamma

    • tropomyosin alpha-3 chain

    • heat-stable cytoskeletal protein 30 kDa

    • cytoskeletal tropomyosin TM30

    • Tropomyosin-5

    • Tropomyosin-3

    • Gamma-tropomyosin
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» Entrez Gene Summary: Rod-like protein associated with actin filament in nonmuscle cells; may mediate the stability of actin filaments; may play a role in the regulation of cell transformation, cytokinesis, motility, and morphogenesis [RGD]. View All» UniProt Summary: FUNCTION: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.SUBUNIT STRUCTURE: Heterodimer of an alpha and a beta chain. Binds to TMOD1 (By similarity).SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton. DOMAIN: The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.SEQUECNE SIMILARITIES: Belongs to the tropomyosin family. View All» Product Name: Anti-Tropomyosin-3, clone 3F8.2 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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