货号：MAB2511Z

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-VCAM-1 Antibody, clone P8B1, Azide Free | MAB2511Z View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: MAB2511Z recognizes the human VCAM-1 molecule. The antibody inhibits VLA-4 (integrin alpha4beta1) binding and recognizes a different epitope than that which is recognized by MAB2144 (P3C4 clone). View All» Clone: P8B1 View All» Isotype: IgG2b View All» Species Reactivity: Human View All» Application Notes: Function blocking Optimal working dilutions must be determined by end user. View All» Presentation: Liquid in 0.2 M phosphate buffer to 0.25 M NaCl, pH 7.6, containing no preservatives. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months. View All» UniProt Number: P19320 View All» Entrez Gene Number:

• NM_001078.2

• NM_080682.1
  View All» Gene Symbol:
  • VCAM1

  • INCAM-100

  • MGC99561

  • CD106

  • DKFZp779G2333

  • L1CAM
    View All» Alternate Names:
    • CD106

    • MAB2511
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Affects Function View All» Entrez Gene Summary: This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P19320 # Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.SIZE: 739 amino acids; 81276 Da SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.DOMAIN: SwissProt: P19320 Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.PTM: Sialoglycoprotein.DISEASE:SwissProt: P19320 # May play an important role in the genesis of atherosclerosis and rheumatoid arthritis.SIMILARITY: Contains 7 Ig-like C2-type (immunoglobulin-like) domains. View All» Brand Family: Chemicon View All» Product Name: Anti-VCAM-1 Antibody, clone P8B1, Azide Free | MAB2511Z View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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