货号：MAB2600

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Glypican-1 Antibody, clone 4D1 | MAB2600 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: MAB2600 recognizes glypican-1. View All» Molecular Weight: Recognizes Glypican-1 at ~ 59 kDa View All» Epitope: Full Length View All» Immunogen: Full length recombinant protein. View All» Clone: 4D1 View All» Isotype: IgG1κ View All» Background Information: Heparan sulfate proteoglycans (HSPGs) can be divided into general categories ofcell-associated forms, including syndecans, glypicans, and secreted extracellular matrix forms, such as perlecan. Glypicans contain six family members to date and are proteins bound to the outer surface of the plasma membrane by a glycosyl-phosphatidylinositol anchor and involved in cellular adhesion and migration and function as accessory molecules for signaling receptors, (Filmus, 2008 & Gui, 2006). Current publications indicate the main function of membrane-attached glypicans is to regulate the signaling of Wnts, Hedgehogs, fibroblast growth factors and bone morphogenetic proteins (BMPs), (Filmus, 2008).Glypican-1 (GPC1) is over-expressed in human gliomas and appears to have a greater capability of promoting FGF-2 signaling in some gliomas versus HSPGs in normal astrocytes. Additional observations suggest that GPC1 can impact the growth of pancreatic cancer cells by attenuating tumor angiogenesis, (Whipple, 2008). View All» Species Reactivity:

• Human

• Rat
  View All» Species Reactivity Note: Human and rat. View All» Application Notes: Immunohistochemistry: A 1:50 dilution of a previous lot detected strong cytoplasmic staining of tumor cells in formalin-fixed, paraffin-embedded gangliobastoma tissue sample. There was negative staining of normal, uninvolved cells. View All» Control: PC-12 cell lysate. View All» Quality Assurance: Routinely evaluated by Western blot on human PC-12 cell lysate using 0.5 µg/mL of Anti-Glypican-1 at 1 mg/mL. View All» Purification Method: Protein G purfied View All» Presentation: Purified in 0.1 M Tris-Glycine (pH 7.4) 150 mM NaCl with 0.05% NaN3. View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt. View All» UniProt Number: P35052 View All» Entrez Gene Number: NP_002072 View All» Gene Symbol:
  • FLJ38078

  • glypican
    View All» Alternate Names:
    • glypican 1

    • glypican proteoglycan 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry (Paraffin)

      • Western Blotting
        View All» Entrez Gene Summary: Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Cell surface proteoglycan that bears heparan sulfate.SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor › GPI-anchor; Extracellular side. Secreted glypican-1: Secreted › extracellular space. PTM: This cell-associated glypican is further processed to give rise to a medium-released species.SEQUENCE SIMILARITIES: Belongs to the glypican family. View All» Product Name: Anti-Glypican-1 Antibody, clone 4D1 | MAB2600 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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