货号：MAB2601

品牌：Merck Millipore

规格：

目录价：￥4626.00

市场价格：￥3932.10

会员价格：￥3700.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CIB1 Antibody, clone 3C5 | MAB2601 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes CIB1. View All» Molecular Weight: ~ 22 kDa View All» Epitope: Unknown View All» Immunogen: Recombinant protein corresponding to human CIB1. View All» Clone: 3C5 View All» Isotype: IgG1κ View All» Background Information: Calcium and integrin binding protein 1 (CIB1) belongs to the calcium-binding protein family and has significant homology to calmodulin and calcineurin B. The specific function of this protein is not well understood; however, CIB1 may regulate various cellular processes by associating with proteins such as FAK and PAK1 which are known to regulate angiogenesis.CIB appers to be a novel Ca2+-binding protein that interacts with the integrin alphaIIb subunit cytoplasmic domain, but not to other integrin cytoplasmic domains. This protein is expressed in platelets and binds to heterodimeric integrin alphaIIb/beta3 (GPIIb/IIIa) as a potential intracellular regulatory molecule, (Naik, 1997). View All» Species Reactivity:

• Mouse

• Human
  View All» Species Reactivity Note: Mouse. Predicted to react with human based on 100% sequence homology. View All» Application Notes: Immunoprecipitation Analysis: A previous lot was used by independent laboratory in IP.Immunocytochemistry Analysis: A previous lot was used by independent laboratory in IC. View All» Control: Mouse spleen tissue lysate View All» Quality Assurance: Evaluated by Western Blot in mouse spleen tissue lysate.Western Blot Analysis: 1 µg/ml of this antibody detected CIB1 on 10 µg of mouse spleen tissue lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q99828 View All» Entrez Gene Number: NP_006375.1 View All» Gene Symbol:
  • CIB1

  • CALMYRIN

  • CIB

  • Calmyrin

  • KIP

  • KIP1

  • PRKDCIP

  • SIP2-28
    View All» Alternate Names:
    • Calmyrin

    • DNA-PKcs-interacting protein

    • DNA-dependent protein kinase interacting protein

    • Kinase-interacting protein

    • KIP

    • SNK-interacting protein 2-28

    • SIP2-28

    • calcium and integrin binding protein
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation

      • Immunocytochemistry
        View All» Entrez Gene Summary: The protein encoded by this gene is a member of the calcium-binding protein family. The specific function of this protein has not yet been determined; however this protein is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end joining. This protein also interacts with integrin alpha(IIb)beta(3), which may implicate this protein as a regulatory molecule for alpha(IIb)beta(3). View All» UniProt Summary: FUNCTION: May convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through the binding to the integrin cytoplasmic domain.SUBUNIT STRUCTURE: Monomer. Interacts with the heterodimeric integrin alpha-IIb/beta3. Interacts with the protein kinases PLK2/SNK and with the region immediately upstream of the kinase domain of DNA-PK. Interacts with PSEN2. Interacts with MYO1C By similarity.SUBCELLULAR LOCATION: Membrane; Lipid-anchor. TISSUE SPECIFICITY: Ubiquitous.SEQUENCE SIMILARITIES: Contains 2 EF-hand domains. View All» Product Name: Anti-CIB1, clone 3C5 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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