货号：MAB2609

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-beta Arrestin 1 Antibody, clone 3H11.2 | MAB2609 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Reacts with human beta-arrestin 1. View All» Molecular Weight: ~47 kDa View All» Epitope: a.a. 357-372 View All» Immunogen: KLH conjugated synthetic peptide corresponding to amino acids 357-372 of human beta arrestin 1. View All» Clone: clone 3H11.2 View All» Isotype: IgMκ View All» Background Information: The Arrestin family consists of four members: Arrestin 1 (visual Arrestin), Arrestin 2 (beta Arrestin 1), Arrestin 3 (beta Arrestin 2), and Arrestin 4 (cone Arrestin). While visual and cone Arrestins are found almost exclusively in the retina, beta Arrestins 1 and 2 are ubiquitously expressed. Beta Arrestins appear to act as negative regulators on G protein-coupled receptors, (Lefkowitz, 1998). Interaction with molecules such as clathrin, AP-2 and NSF directs the clathrin-mediated internalization of G-protein-coupled receptors. Interaction with molecules such as Src, Raf, Erk, ASK1 and JNK3 appears to regulate several pathways that result in the activation of MAP kinases, (Lin, 1998; Miller, 2001). View All» Species Reactivity: Human View All» Species Reactivity Note: Reacts with human. Other species have not been tested. View All» Control: HEK293 cell lysate View All» Quality Assurance: Evaluated on a representative lot by Western blot in HEK293 cell lysate. View All» Purification Method: Ammonium sulfate precipitation View All» Presentation: Purified in PBS with 0.05% NaN3. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt. View All» UniProt Number: P49407 View All» Entrez Gene Number: NP_004032.2 View All» Gene Symbol:

• ARRESTIN

• S-AG

• S-arrestin
  View All» Alternate Names:
  • Retinal S-antigen

  • Rod photoreceptor arrestin

  • S-antigen; retina and pineal gland (arrestin)

  • arrestin 1

  • retinal S-antigen (48 KDa protein)
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunofluorescence
      View All» Entrez Gene Summary: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known. [provided by RefSeq] View All» UniProt Summary: FUNCTION: Regulates beta-adrenergic receptor function. Beta-arrestins seem to bind phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate G(S) proteins.SEQUENCE SIMILARITIES: Belongs to the arrestin family. View All» Product Name: Anti-beta Arrestin 1 Antibody, clone 3H11.2 | MAB2609 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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