货号：MAB2613

品牌：Merck Millipore

规格：100Ug

目录价：￥6281.00

市场价格：￥5338.85

会员价格：￥5024.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-UPAR-Associated Protein Antibody, clone 2.h.9:F12 | MAB2613 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes UPAR-Associated Protein. View All» Molecular Weight: ~ 180 kDa View All» Epitope: Unknown View All» Immunogen: uPAR D3-tagged recombinant protein corresponding to human UPAR-Associated Protein. View All» Clone: 2.h.9:F12 View All» Isotype: IgG1κ View All» Background Information: Urokinase plasminogen activator receptor-associated protein (uPARAP/Endo180/MRC2) is a member of the macrophage mannose receptor family of endocytic transmembrane glycoproteins. UPAR-Associated Protein is a membrane protein involved in matrix turnover during tissue remodeling, particularly the uptake and intracellular degradation of collagen, (Sulek, 2007). View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Human and mouse. View All» Control: U937 cell lysate View All» Quality Assurance: Evaluated by Western Blot in U937 cell lysate.Western Blot Analysis: 0.2 µg/ml of this antibody detected UPAR-Associated Protein on 10 µg of U937 cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9UBG0 View All» Entrez Gene Number: NP_006030.2 View All» Gene Symbol:
  • MRC2

  • CD280

  • CLEC13E

  • ENDO180

  • UPARAP
    View All» Alternate Names:
    • CD280

    • Endocytic receptor 180

    • Macrophage mannose receptor 2

    • UPAR-associated protein

    • Urokinase receptor-associated protein

    • Endocytic receptor 180

    • C-type mannose receptor 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» Entrez Gene Summary: MRC2 is a recycling endocytic receptor that functions in cell motility and remodeling of the extracellular matrix by promoting cell migration and uptake of collagens for intracellular degradation (Wienke et al., 2007 [PubMed 17974964]).[supplied by OMIM]. View All» UniProt Summary: FUNCTION: May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix co-operating with the matrix metalloproteinases (MMPs). SUBUNIT STRUCTURE: Interacts with C-terminal region of type I collagen/COL1A1 By similarity. Interacts directly with PLAUR/UPAR and PLAU/pro-UPA to form a tri-molecular complex. Interacts with collagen V.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney. DOMAIN: C-type lectin domains 3 to 8 are not required for calcium-dependent binding of mannose, fucose and N-acetylglucosamine. C-type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner. Fibronectin type-II domain mediates collagen-binding. Ricin B-type lectin domain contacts with the second C-type lectin domain By similarity.PTM: Phosphorylated.N-glycosylated. SEQUENCE SIMILARITIES: Contains 8 C-type lectin domains.Contains 1 fibronectin type-II domain.Contains 1 ricin B-type lectin domain. View All» Product Name: Anti-UPAR-Associated Protein, clone 2.h.9:F12 View All» Concentration: 0.25 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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