货号：MAB2617

品牌：Merck Millipore

规格：100Ug

目录价：￥5359.00

市场价格：￥4555.15

会员价格：￥4287.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Kindlin-2 Antibody, clone 3A3 | MAB2617 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes Kindlin-2. View All» Molecular Weight: ~ 70 kDa View All» Epitope: Unknown View All» Immunogen: GST-tagged recombinant protein corresponding to human Kindlin-2. View All» Clone: 3A3 View All» Isotype: IgG1κ View All» Background Information: The Kindlin family is a group of focal adhesion proteins that have become a point of interest because of their ability to bind and activate integrins. Abnormalities in this ability have linked Kindlin to several diseases, both inherited and acquired, such as Kindler syndrome, cancer, and leukocyte adhesion deficiency. The isoform Kindlin-2 specifically participates in the recruitment of migfilin protein to focal adhesion sites for cell-ECM interactions, coordinates the manufacture of actin and modifications to cell shape. It is also actively involved in connecting ECM adhesion sites and the actin cytoskeleton (Shi, 2007). Kindlin-2 is pervasively expressed throughout tissue. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Bovine
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with bovine based on 100% sequence homology.Mouse and rat (98% sequence homology). View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 0.5 µg/ml of this antibody detected Kindlin-2 in 10 µg of HeLa cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q96AC1 View All» Entrez Gene Number: NP_001128471 View All» Gene Symbol:
  • FERMT2

  • KIND2

  • Kindlin-2

  • MIG-2

  • MIG2

  • PLEKHC1

  • UNC112

  • UNC112B

  • kindlin-2

  • mig-2
    View All» Alternate Names:
    • Mitogen-inducible gene 2 protein

    • Pleckstrin homology domain-containing family C member 1

    • fermitin family homolog 2

    • kindlin 2

    • mitogen inducible gene 2 protein
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» UniProt Summary: FUNCTION: Participates in the connection between ECM adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits migfilin (FBLP1) protein to cell-ECM focal adhesion sites. SUBUNIT STRUCTURE: Interacts with FBLP1. SUBCELLULAR LOCATION: Cytoplasm › cell cortex. Cytoplasm › cytoskeleton. Cell junction › focal adhesion. Note: Within actin stress fibers at cell-ECM focal adhesion sites. TISSUE SPECIFICTY: Ubiquitous. Found in numerous tumor tissues.INDUCTION: By serum, in lung fetal fibroblast cultured cells. DOMAIN: The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain.SEQUENCE SIMILARITIES: Belongs to the kindlin family.Contains 1 FERM domain.Contains 1 PH domain. View All» Product Name: Anti-Kindlin-2, clone 3A3 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
        © 金山科研平台是专业的授权总代理区域代理经销平台。
        © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
        © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
        © 本文地址：https://www.16ao.com/thread-130735.htm
        © Merck Millipore代理MAB2617 Anti-Kindlin-2 Antibody, clone 3A3;抗Kindlin-2抗体，克隆3A3store at +2℃ to +8℃，产品报价联系微信jinshanbio