货号：MAB2621

品牌：Merck Millipore

规格：EA

目录价：￥3673.00

市场价格：￥3122.05

会员价格：￥2938.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Gamma-parvin Antibody, clone 8C5.2 | MAB2621 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Gamma-parvin. View All» Molecular Weight: ~ 38 kDa View All» Epitope: Unknown View All» Immunogen: GST-tagged recombinant protein corresponding to human Gamma-parvin. View All» Clone: 8C5.2 View All» Isotype: IgG1κ View All» Background Information: The parvins are a family of proteins involved in linking integrins and associated proteins with intracellular pathways that regulate actin cytoskeletal dynamics and cell survival. Gamma-Parvin is specifically expressed in several lymphoid and monocytic cell lines in a complementary manner to affixin. Like beta-parvin or affixin, gamma-parvin directly associates with ILK through its CH2 domain and colocalizes with ILK at focal adhesions as well as the leading edge of PMA-stimulated U937 cells plated on fibronectin. The overexpression of the C-terminal fragment containing CH2 domain or the depletion of Gamma-parvin by RNA interference inhibits the substrate adhesion of MCP-1-stimulated U937 cells and the spreading of PMA-stimulated U937 cells on fibronectin. Interestingly, the overexpression of the CH2 fragment or the Gamma-parvin RNA interference also disrupts the asymmetric distribution of PTEN and F-actin observed at the very early stage of cell spreading, suggesting that the ILK-gamma-parvin complex is essential for the establishment of cell polarity required for leukocyte migration (Yoshimi, 2006). View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP. (Yoshimi, R., et al. (2006). J Immunol. 176(6):3611-3624.)Immunofluorescence Analysis: A previous lot was used by an independent laboratory in IF. (Yoshimi, R., et al. (2006). J Immunol. 176(6):3611-3624.) View All» Control: Jurkat cell lysate View All» Quality Assurance: Evaluated by Western Blot in Jurkat cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Gamma-parvin in 10 µg of Jurkat cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9HBI0 View All» Entrez Gene Number: NP_001131077 View All» Gene Symbol: PARVG View All» Alternate Names:

• parvin-gamma

• gamma parvin
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunoprecipitation
    View All» UniProt Summary: FUNCTION: Probably plays a role in the regulation of cell adhesion and cytoskeleton organization (By similarity).SUBUNIT STRUCTURE: Interacts with integrin-linked protein kinase and actin By similarity.SUBCELLULAR LOCATION: Cell junction › focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasm › cytoskeleton (By similarity). Note: Constituent of focal adhesions (By similarity).TISSUE SPECIFICITY: Expressed predominantly in lymphoid organs, including spleen, thymus, lymph node, bone marrow and peripheral blood leukocytes and moderately in the digestive tract, including stomach, duodenum, jejunum, ileum, ileocecum and appendix, as well as in lung and liver. Also expressed in tumors, but at a lower level than in the corresponding normal tissues. SEQUENCE SIMILARITIES: Belongs to the parvin family.Contains 2 CH (calponin-homology) domains. View All» Product Name: Anti-Gamma-parvin, clone 8C5.2 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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