货号：MAB2627

品牌：Merck Millipore

规格：100Ug

目录价：￥4967.00

市场价格：￥4221.95

会员价格：￥3973.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-VCAM-1 (CD106) Antibody, clone 6C7.1 | MAB2627 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: 81 kDa calculated View All» Immunogen: Mouse endothelial cells View All» Clone: 6C7.1 View All» Isotype: IgG1κ View All» Background Information: Vascular cell adhesion protein 1 (VCAM-1) is a cell surface adhesion molecule belonging to the immunoglobulin cell-cell adhesion receptor family and is comprised of seven Ig-like C2-type domains. VCAM-1 is a crucial component in cell-cell recognition and seems to be involved in cellular adhesion between endothelial cells and leukocytes. It has a regulatory role for both signal transduction and adhesion through its interaction with leukocyte beta-1 integrin VLA4, an interaction that is potentially involved in immune and inflammatory emigration responses of leukocytes. Studies have shown upregulation of VCAM-1 to be critical in responding to inflammatory diseases such as atherosclerosis. VCAM-1 is primarily expressed in endothelial cells and is expressed as two known isoforms found within the cell membrane. Isoform 1 functions as a single-pass type 1 membrane protein, while Isoform 2 acts as a GPI-anchor. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with mouse. View All» Application Notes: Immunohistochemistry Analysis: A previous lot was used by independent laboratory in IH. (Norman, U., et al. (2008). Journal of Leukocyte Biology. 84:68-76.)Immunocytochemistry Analysis: A previous lot was used by independent laboratory in IC. (Norman, U., et al. (2008). Journal of Leukocyte Biology. 84:68-76.) View All» Control: Mouse bone marrow cells View All» Quality Assurance: Evaluated by Flow Cytometry in mouse bone marrow cells.Flow Cytometry Analysis: 10 µg of this antibody detected VCAM-1 on mouse bone marrow cells. View All» Purification Method: Protein G View All» Presentation: Purified rat monoclonal IgG1κ in buffer containing PBS without preservative. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P29533 View All» Entrez Gene Number: NP_035823 View All» Gene Symbol:

• VCAM1

• VCAM-1

• CD106

• V-CAM 1

• INCAM-100

• L1CAM
  View All» Alternate Names:
  • vascular cell adhesion molecule 1

  • vascular cell adhesion protein 1

  • CD106 antigen
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Immunoprecipitation

    • Immunocytochemistry

    • Immunohistochemistry
      View All» UniProt Summary: FUNCTION: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.SUBUNIT STRUCTURE: Binds to ECMV-D capsid proteins and acts as a receptor for this virus. SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Lipid-anchor › GPI-anchor. TISSUE SPECIFICTY: Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Expressed in the bone marrow. PTM: The GPI-anchor is located on position 319 of isoform 2.SEQUENCE SIMILARITIES: Contains 7 Ig-like C2-type (immunoglobulin-like) domains. View All» Product Name: Anti-VCAM-1 (CD106), clone 6C7.1 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rat View All»
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