货号：MAB2636

品牌：Merck Millipore

规格：100Ug

目录价：￥5359.00

市场价格：￥4555.15

会员价格：￥4287.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SERCA2 Antibody, clone IID8 | MAB2636 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes SERCA2. View All» Molecular Weight: ~ 110 kDa View All» Epitope: Unknown View All» Immunogen: Purified canine cardiac sarcoplasmic reticulum. View All» Clone: IID8 View All» Isotype: IgG1κ View All» Background Information: The sarcoplasmic reticulum of striated muscle is a specialized intracellular membrane system that plays a critical role in the contraction and relaxation of muscle. The sarco/endoplasmic reticulum Ca2+ ATPases (SERCAs) mediate Ca2+ uptake into intracellular stores. SERCA mediated Ca2+ uptake induces and maintains muscular relaxation. SERCA1 is expressed in fast-twitch muscles, whereas SERCA2 is expressed in cardiac and slow-twitch muscles. SERCA2 plays an important part in regulating cardiac contractile function. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: Immunocytochemistry Analysis: A previous lot was used by an independent laboratory in IC (Eizema, 2007). View All» Control: HEK293 cell lysate View All» Quality Assurance: Evaluated by Western Blot in HEK293 cell lysate.Western Blot Analysis: 0.5 µg/ml of the antibody detected SERCA2 in 10 µg of HEK293 cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O46674 View All» Entrez Gene Number: NP_001003214 View All» Gene Symbol:

• ATP2A2

• ATP2B

• DAR

• DD

• SERCA2
  View All» Alternate Names:
  • Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

  • SR Ca(2+)-ATPase 2

  • ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

  • Calcium pump 2

  • Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform

  • Endoplasmic reticulum class 1/2 Ca(2+) ATPase

  • SR Ca(2+)-ATPase 2

  • cardiac Ca2+ ATPase
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry

    • Immunohistochemistry
      View All» UniProt Summary: FUNCTION: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle By similarity.CATALYTIC ACTIVITY: ATP + H2O + Ca2+(Cis) = ADP + phosphate + Ca2+(Trans).ENZYME REGULATION: Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN.SUBUNIT STRUCTURE: Associated with phospholamban (PLN). Isoform SERCA2B interacts with TRAM2 (via C-terminus). Interacts with HAX1 By similarity.SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Isoform SERCA2A is highly expressed in heart and slow twitch skeletal muscle. Isoform SERCA2B is widely expressed.PTM: Nitrated under oxidative stress. Nitration on the two tyrosine residues inhibits catalytic activity By similarity.SEQUENCE SIMILARITIES: Belongs to the cation transport ATPase (P-type) family. Type IIA subfamily. View All» Product Name: Anti-SERCA2, clone IID8 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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