货号：MAB303

品牌：Merck Millipore

规格：100Ug

目录价：￥4292.00

市场价格：￥3648.20

会员价格：￥3433.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Acetylcholinesterase Antibody, clone AE-1 | MAB303 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Acetylcholinesterase from human and monkey. View All» Immunogen: Acetylcholinesterase AChE from human erythrocyte. View All» Clone: AE-1 View All» Isotype: IgG1 View All» Species Reactivity:

• Bovine

• Canine

• Chicken

• Guinea Pig

• Human

• Monkey
  View All» Application Notes: ELISA Immunohistochemistry Western Blot Optimal working dilutions must be determined by end user. View All» Presentation: Liquid in 0.02M PB, 0.25M NaCl, pH 7.6, with 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C for up to 6 months. View All» UniProt Number: P22303 View All» Entrez Gene Number:
  • NM_000665.3

  • NM_015831.2
    View All» Gene Symbol:
    • ACHE

    • N-ACHE

    • acetylcholinesterase

    • AChE

    • YT

    • ARACHE

    • EC 3.1.1.7
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • ELISA

      • Immunohistochemistry

      • Immunoprecipitation
        View All» Entrez Gene Summary: Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. View All» UniProt Summary: FUNCTION: SwissProt: P22303 # Rapidly hydrolyzes choline released into the synapse.SIZE: 614 amino acids; 67796 Da SUBUNIT: Homotetramer; composed of disulfide-linked homodimers. Interacts with PRIMA1. The interaction with PRIMA1 is required to anchor it to the basal lamina of cells and organize into tetramers (By similarity).SUBCELLULAR LOCATION: Cell junction, synapse. Secreted (By similarity). Cell membrane; Peripheral membrane protein (By similarity). & Isoform 2: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side (By similarity).SIMILARITY: SwissProt: P22303 ## Belongs to the type-B carboxylesterase/lipase family. View All» Brand Family: Chemicon View All» Product Name: Anti-Acetylcholinesterase Antibody, clone AE-1 | MAB303 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Target / Localization: Cholinergic, Perisynaptic View All» Format: Purified View All» Host: Mouse View All»
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