货号：MAB3070

品牌：Merck Millipore

规格：250UL

目录价：￥5359.00

市场价格：￥4555.15

会员价格：￥4287.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Granzyme B Antibody, clone GrB-7 | MAB3070 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Monoclonal antibody recognizes the 33 kDa granzyme B. Reacts specifically with human serine protease granzyme B. Does not cross-react with human granzyme A. Granzyme B localizes in cytoplasmic granules and can be used as a marker for NK cells and activated cytotoxic T-cells. View All» Clone: GrB-7 View All» Isotype: IgG2a View All» Species Reactivity: Human View All» Application Notes: Immunoblotting Immunohistochemistry of granzyme B-expressing lymphocytes in sublimate sections and formalin-fixed paraffin-embedded tissues (1:20 dilution). Does not react with other cell types. Cannot be used on frozen sections. Note on the use of MAB3070 on paraffin sections: Tissue slides should be pretreated with an antigen retrieval method, such as treatment with 0.1M sodium citrate for 10 min at 100°C. A working dilution of 1:20 is advised, but optimal working dilutions must be determined by end user. View All» Presentation: Liquid View All» Storage Conditions: Maintain at -20°C for up to 12 months. View All» UniProt Number: P10144 View All» Entrez Gene Number: NM_004131.3 View All» Gene Symbol:

• GZMB

• GRB

• CGL-1

• CCPI

• CSP-B

• C11

• CTLA1

• CTLA-1

• Granzyme-2

• CSPB

• SECT

• Fragmentin-2

• CGL1

• HLP

• CTSGL1

• EC 3.4.21.79
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunohistochemistry (Paraffin)
    View All» Entrez Gene Summary: Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. View All» UniProt Summary: FUNCTION: SwissProt: P10144 # This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.SIZE: 247 amino acids; 27688 Da SUBCELLULAR LOCATION: Cytoplasmic granule. Note=Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.SIMILARITY: SwissProt: P10144 ## Belongs to the peptidase S1 family. Granzyme subfamily. & Contains 1 peptidase S1 domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Granzyme B Antibody, clone GrB-7 | MAB3070 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 250 µL View All» Format: Culture Supernatant View All» Host: Mouse View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://www.16ao.com/thread-130810.htm
    © Merck Millipore代理MAB3070 Anti-Granzyme B Antibody, clone GrB-7;store at -20℃，产品报价联系微信jinshanbio