货号：MAB308

品牌：Merck Millipore

规格：100UL

目录价：￥5359.00

市场价格：￥4555.15

会员价格：￥4287.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Dopamine β Hydroxylase Antibody, clone 4F10.2 | MAB308 View All» Replaces: MAB394-250UG, MAB394-100UG and MAB394-25UG View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Dopamine beta hydroxylase (DBH). View All» Immunogen: Purified bovine DBH. View All» Clone: 4F10.2 View All» Isotype: IgG1 View All» Background Information: Dopamine Beta Hydroxylase (DBH), the structural locus encoding DβH enzyme, is a major quantitative trait locus influencing plasma DβH activity, with one single nucleotide polymorphism (SNP) accounting for up to 50% of the variance. Mutations at DBH appear to be responsible for the rare syndrome of DβH deficiency. It functions as the only enzyme involved in the synthesis of small-molecule neurotransmitters that is membrane-bound, making norepinephrine and epinephrine the only transmitters synthesized inside vesicles. It is expressed in noradrenergic nerve terminals of the central and peripheral nervous systems, as well as in chromaffin cells of the adrenal medulla. View All» Species Reactivity:

• Bovine

• Rat

• Sheep
  View All» Species Reactivity Note: Bovine, Rat and Sheep View All» Application Notes: Indirect immunofluorescence: 1:300-1:500 dilution of a previous lot was used on rat brain tissue. Optimal working dilutions must be determined by the end user.Immunohistochemistry(paraffin): Representative images from a previous lot.Optimal Staining With Citrate Buffer, pH 6.0, Epitope Retrieval: Rat Spinal Cord View All» Control: Brain (Striatum/Substantia Nigra) View All» Quality Assurance: Immunohistochemistry(paraffin): Dopamine β Hydroxylase (cat. # MAB308) staining pattern/morphology in rat spinal cord. Tissue was pretreated with Citrate, pH 6.0. This lot of antibody was diluted to 1:300, using IHC-Select® Detection with HRP-DAB. Immunoreactivity is seen predominantly expressed in the dorsal root ganglia (DRG).Optimal Staining With Citrate Buffer, pH 6.0, Epitope Retrieval: Rat Spinal Cord View All» Purification Method: Unpurified View All» Presentation: Ascites mouse monoclonal IgG1 in liquid with 0.1% sodium azide. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. View All» UniProt Number: P09172 View All» Entrez Gene Number: NM_000787.3 View All» Gene Symbol:
  • DBH

  • DBM

  • EC 1.14.17.1 [Contains: Soluble dopamine beta-hydroxylase].
    View All» Alternate Names: DBH View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunohistochemistry

    • Immunohistochemistry (Paraffin)

    • Immunofluorescence
      View All» Entrez Gene Summary: The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. View All» UniProt Summary: FUNCTION: SwissProt: P09172 # Conversion of dopamine to noradrenaline.COFACTOR: Binds 1 PQQ per subunit. & Binds 2 copper ions per subunit.SIZE: 617 amino acids; 69065 Da SUBUNIT: Homotetramer composed of two non-covalently bound disulfide-linked dimers.SUBCELLULAR LOCATION: Soluble dopamine beta-hydroxylase: Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen. & Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type II membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single- pass type II membrane protein (Potential).DISEASE: SwissProt: P09172 # Defects in DBH are the cause of DBH deficiency [MIM:223360]; also called norepinephrine deficiency or noradrenaline deficiency. This disorder is characterized by profound deficits in autonomic and cardiovascular function, but apparently only subtle signs, if any, of central nervous system dysfunction.SIMILARITY: SwissProt: P09172 ## Belongs to the copper type II ascorbate-dependent monooxygenase family. & Contains 1 DOMON domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Dopamine β Hydroxylase Antibody, clone 4F10.2 | MAB308 View All» Concentration: Variable View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Target / Localization: Cytoplasmic View All» Format: Ascites View All» Host: Mouse View All»
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      © Merck Millipore代理MAB308 Anti-Dopamine β Hydroxylase Antibody, clone 4F10.2;抗多巴胺β羟化酶抗体，克隆4F10.2store at -20℃，产品报价联系微信jinshanbio