货号：MAB3104

品牌：Merck Millipore

规格：

目录价：￥3908.00

市场价格：￥3321.80

会员价格：￥3126.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Calpain I Antibody, large subunit, clone P9 | MAB3104 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with human calpain-I (μ-Calpain). P9 does not cross with human placental m-calpain (calpain II). This antibody will immunoprecipitate proteolytically active calpains. View All» Epitope: large subunit View All» Immunogen: Calpain-I large subunit from human erythrocyte calpain. View All» Clone: P9 View All» Isotype: IgG1 View All» Background Information: Calpains are non-lysosomal cysteine proteeases which absolutely require calcium for activity. There are two major calpain isozymes: μ-calpain and m-calpain, which require micromolar or millimolar calicum for activity, respectively, in invitro assays. The major calpain isozymes are composed of two subunits: an 80kDa catalytic subunit; and a 30kDa regulatory subunit. The large and small subunits remain associated in the presence of calcium after proteolytic activation of the zymogen. View All» Species Reactivity:

• Human

• Hamster

• Mouse

• Rat
  View All» Non-Reactive Species: Canine View All» Application Notes: Immunoblot: 1:1,000 Detects an 80kDa large subunit μ-calpain, and will also detect the subunit in the non-activated proform of the zymogen, showing a band of ~110kDa. WI-38 human fibroblasts, or human erthryocytes are suggested as positive controls. Immunocytochemistry: 1:100 on A431 epidermal carcinoma. Immunoprecipitation ELISA: 1:6,000 (against the immunogen) Optimal working dilutions must be determined by the end user. View All» Control: WI-38 human fibroblasts, or human erthryocytes are suggested as positive controls. View All» Presentation: Liquid View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P07384 View All» Entrez Gene Number: NM_005186.2 View All» Gene Symbol:
  • CAPN1

  • CANPL1

  • muCANP

  • CANP

  • muCL

  • Micromolar-calpain

  • EC 3.4.22.52
    View All» Alternate Names: mu-Calpain; μ-Calpain View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Immunoprecipitation

    • Western Blotting

    • Immunocytochemistry
      View All» Entrez Gene Summary: The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. View All» UniProt Summary: FUNCTION: SwissProt: P07384 # Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.COFACTOR: Binds 3 calcium ions.SIZE: 714 amino acids; 81890 Da SUBUNIT: Forms a heterodimer with a small (regulatory) subunit (CAPNS1).SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Translocates to the plasma membrane upon Ca(2+) binding (By similarity).TISSUE SPECIFICITY: Ubiquitous.SIMILARITY: SwissProt: P07384 ## Belongs to the peptidase C2 family. & Contains 1 calpain catalytic domain. & Contains 4 EF-hand domains. View All» Brand Family: Chemicon View All» Product Name: Anti-Calpain I Antibody, large subunit, clone P9 | MAB3104 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Ascites View All» Host: Mouse View All»
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