货号：MAB3140

品牌：Merck Millipore

规格：100Ug

目录价：￥5820.00

市场价格：￥4947.00

会员价格：￥4656.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Na+/H+ Exchanger-1 Antibody, C-terminus, clone 4E9 | MAB3140 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Na+/H+ exchanger, isoform NHE1 View All» Molecular Weight: ~100-110 kDa View All» Epitope: C-terminus View All» Immunogen: MBP fusion protein containing the entire C-terminal, hydrophylic domain of porcine NHE1. View All» Clone: 4E9 View All» Isotype: IgG1 View All» Background Information: Mammalian NHE (Na+/H+ Exchanger) is an integral membrane protein that is known to regulate intracellular pH by removing a proton in exchange for an extracellular sodium ion. There are nine known isofoms of NHE. The best characterized is NHE1, involved not only in intracellular pH control, but cell-volume control, cytoskeletal organization, heart disease and cancer. Transport by the NHE plays a pivotal role in the damage caused to the human myocardium during and following a myocardial infarction, and it is considered to represent a key step in the oncogenic transformation of cancerous cells. NHE comprises an N-terminal membrane domain that transports ions, and a C-terminal cytoplasmic domain that regulates activity and mediates cytoskeletal interactions. NHE2 - NHE5 isoforms are localized to the plasma membrane but exhibit greater tissue-specificity. NH2 and NH3 are more highly expressed in the kidney and intestine. Structurally, a single transmembrane segment from NHE1 has been solved, and the structure of bacterial Na+/H+ antiporter NhaA has been elucidated. View All» Species Reactivity:

• Vertebrates

• Fish

• Amphibian

• Avian

• Mammals
  View All» Species Reactivity Note: All vertebrates including fish, amphibians, birds and mammals. Expected to react with rat and mouse based on sequence homology. View All» Application Notes: Works poorly for immunohistochemistry and immunocytochemistry.Not recommended for immunoprecipitation.Immunoblotting: 1:1,000 dilution used on a previous lot.Optimal working dilutions must be determined by the user. View All» Applications Not Recommended: Immunoprecipitation View All» Control: Kidney tissue (basolateral membrane) View All» Quality Assurance: Routinely evaluated by Western Blot on Human Kidney lysates.Western Blot: 1:500 dilution of this lot detected Na+/H+ Exchanger-1 on 10 μg of Human Kidney lysates. View All» Purification Method: Protein A purfied View All» Presentation: Purified mouse monoclonal IgG1 liquid in buffer containing 0.02M Phosphate buffer, 0.25M NaCl, pH 7.6 with 0.1% sodium azide View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt. View All» UniProt Number: P19634 View All» Entrez Gene Number: NM_003047.2 View All» Gene Symbol:
  • SLC9A1

  • FLJ42224

  • APNH

  • NHE-1

  • Na

  • +H

  • NHE1

  • APNH1
    View All» Alternate Names: NHE1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: SwissProt: P19634 # Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.SIZE: 815 amino acids; 90763 Da SUBUNIT: Interacts with tescalcin, CHP and CHP2.SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Kidney and intestine.PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. & O-glycosylated.SIMILARITY: SwissProt: P19634 ## Belongs to the Na(+)/H(+) exchanger (TC 2.A.36.5.1) family. MISCELLANEOUS: Inhibited by amiloride and 5-amino-substituted derivatives and activated in a cooperative fashion by intracellular H(+). In quiescent cells upon growth factor stimulation, the apparent affinity for internal H(+) is increased, resulting in a persistent rise in cytoplasmic pH." View All» Brand Family: Chemicon View All» Product Name: Anti-Na+/H+ Exchanger-1 Antibody, C-terminus, clone 4E9 | MAB3140 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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