货号：MAB318

品牌：Merck Millipore

规格：100UL

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Tyrosine Hydroxylase Antibody, clone LNC1 | MAB318 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes an epitope on the outside of the regulatory N-terminus. Recognizes a protein of approximately 59-61 kDa by Western blot. Does not react with the following on Western Blots: dopamine-beta-hydroxylase, phenylalanine hydroxylase, trytophan hydroxylase, dehydropteridine reductase, sepiapterin reductase or phenethanolamine-N-methyl transferase (PNMT). View All» Molecular Weight: 59-63 kDa View All» Immunogen: Tyrosine Hydroxylase purified from PC12 cells View All» Clone: LNC1 View All» Isotype: IgG1κ View All» Background Information: Tyrosine hydroxylase plays an important role in the physiology of adrenergic neurons. It is the first and rate-limiting enzyme involved in the biosynthesis of the catecholamines Dopamine and Norepinephrine from tyrosine. TH is, therefore, a useful marker for dopaminergic and noradrenergic neurons. The enzymatic activity of TH requires ferrous ions as cofactors and is believed to be regulated by phosphorylation. At least four isoforms of human TH have been identified which result from alternative splicing. View All» Species Reactivity:

• Chicken

• Frog

• Human

• Mouse

• Monkey

• Rat

• Lizard

• Vole

• Zebrafish
  View All» Species Reactivity Note: Human, mouse, rat, chicken, frog, lizard, monkey, vole and zebrafish. View All» Application Notes: Immunohistochemistry(paraffin): A 1:200-1:400 dilution of a previous lot was used in IH. 4% PFA fixed, frozen sections; 4% PFA fixed, paraffin sections 1:100 (Barrachina, M. et al., 2003). For paraffin sections Barrachina reported successful staining with microwave citrate acid antigen recovery, however other methods can likely be used as well.Immunoprecipitation: A previous lot of this antibody was used in IP (Perez, 2002).Optimal working dilutions and protocols must be determined by end user. View All» Control: Human brain tissue, extracts from 3T3 cells treated with Forskolin (40 nM, 30 min). View All» Quality Assurance: Routinely evaluated by Western Blot on Mouse Brain lysates.Western blot: 1:1000 dilution of this lot detected Tyrosine Hydroxylase on 10 μg of Mouse Brain lysates. View All» Purification Method: Unpurified View All» Presentation: Ascites mouse monoclonal IgG1κ fluid containing 3% BSA. Contains no preservative. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. View All» UniProt Number: P07101 View All» Entrez Gene Number: NM_000360.3 View All» Gene Symbol:
  • TH

  • TYH

  • EC 1.14.16.2
    View All» Alternate Names:
    • TH

    • Tyrosine Monooxygenase
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry

      • Immunohistochemistry (Paraffin)

      • Immunoprecipitation

      • Western Blotting
        View All» Entrez Gene Summary: Tyrosine hydroxylase is involved in the conversion of tyrosine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. View All» UniProt Summary: FUNCTION: SwissProt: P07101 # Plays an important role in the physiology of adrenergic neurons.COFACTOR: Fe(2+) ion.SIZE: 528 amino acids; 58524 Da TISSUE SPECIFICITY: Mainly expressed in the brain and adrenal glands.DISEASE: SwissProt: P07101 # Defects in TH are the cause of autosomal recessive Segawa syndrome [MIM:605407]; also known as DOPA-responsive dystonia. Typically, it begins in childhood or adolescence with progressive difficulty in walking and, in some cases, spasticity. Some cases present with parkinsonian symptoms in infancy and are referred to as autosomal recessive infantile parkinsonism.SIMILARITY: SwissProt: P07101 ## Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. View All» Brand Family: Chemicon View All» Product Name: Anti-Tyrosine Hydroxylase Antibody, clone LNC1 | MAB318 View All» Concentration: Variable View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Target / Localization: Cytoplasmic, adrenergic neuron lineage View All» Format: Ascites View All» Host: Mouse View All»
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